Yao Qiong, Hu Xi-Hong, Shen Quan-Li, Qiao Zhong-Wei, Pa Mi-Er, Qian Bin, Yan Wei-Li, Huang Guo-Ying
Department of Radiology, Children's Hospital of Fudan University, Shanghai, PR China.
Cardiology. 2016;133(3):135-40. doi: 10.1159/000441291. Epub 2015 Nov 5.
We aimed to compare the diagnostic value of indexed right ventricular end-diastolic volume (RVEDVi) and the ratio of right ventricle volume to left ventricle volume (RV/LV ratio) in prediction of the severity of pulmonary regurgitation (PR) expressed as the PR fraction (PRF) after surgery of tetralogy of Fallot (TOF). Forty-one patients with repaired TOF were included in the study. RVEDVi, LVEDVi, RV/LV ratio, PRF and ejection fraction were measured with magnetic resonance imaging. A PRF of more than 20% was considered significant. The predictive capability of two markers (RVEDVi and RV/LV ratio) for significant PR was compared using multivariate linear regression analysis and receiver operating characteristic (ROC) analysis. Both the RV/LV ratio and RVEDVi showed a correlation with PRF (r = 0.526/0.321, p = 0.001/0.041) in the correlation analysis, but in multivariate regression analysis the only independent predictor of PRF was the RV/LV ratio (F = 14.890, p = 0.001). ROC analysis revealed that a better discrimination of significant PR (>20%) from slight types (=20%) PR can be reached with the RV/LV ratio than RVEDVi (AUC = 0.805/0.709, p = 0.01). The RV/LV ratio was better than RVEDVi at differentiating mild from moderate PR (p = 0.006 vs. p = 0.153), and proved superior over RVEDVi in predicting PR based on the PRF criterion.
我们旨在比较指数化右心室舒张末期容积（RVEDVi）和右心室容积与左心室容积之比（RV/LV比）对法洛四联症（TOF）术后以肺动脉反流分数（PRF）表示的肺动脉反流（PR）严重程度的预测价值。41例TOF修复术后患者纳入本研究。采用磁共振成像测量RVEDVi、左心室舒张末期容积（LVEDVi）、RV/LV比、PRF和射血分数。PRF大于20%被认为具有显著性。使用多变量线性回归分析和受试者工作特征（ROC）分析比较两种标志物（RVEDVi和RV/LV比）对显著性PR的预测能力。相关性分析中，RV/LV比和RVEDVi均与PRF相关（r = 0.526/0.321，p = 0.001/0.041），但在多变量回归分析中，PRF的唯一独立预测因子是RV/LV比（F = 14.890，p = 0.001）。ROC分析显示，与RVEDVi相比，RV/LV比对显著性PR（>20%）与轻度PR（<=20%）的区分能力更好（AUC = 0.805/0.709，p = 0.01）。在区分轻度与中度PR方面，RV/LV比优于RVEDVi（p = 0.006对p = 0.153），并且在基于PRF标准预测PR方面，RV/LV比证明优于RVEDVi。
