Trenholme G M, Schmitt B A, Nelson J A, Gvazdinskas L C, Harrison B B, Parkhurst G W
Department of Medicine, Presbyterian-St. Luke's Medical Center Chicago, Illinois 60612.
Diagn Microbiol Infect Dis. 1989 Jan-Feb;12(1):107-11. doi: 10.1016/0732-8893(89)90054-0.
Thirty-one patients with Gram-negative bacteremia with organisms susceptible to cefotaxime (CTX) (MIC of 1 microgram/ml or less) were randomized to receive 2 g of CTX every 6, 8, or 12 hr. Five-hour susceptibility studies were performed on a bacterial pellet obtained from the patient's positive blood culture vial. Thus, patients were enrolled within hours after Gram-negative organisms were demonstrated in their blood cultures. All bacteremias were cleared although two patients had unsatisfactory responses to therapy. Trough serum bactericidal levels were 1:2 or greater in all patients. This study supports that CTX can be used at an 8- or 12-hr intervals in selected patients with Gram-negative bacteremia.
31例革兰阴性菌血症患者，其病原菌对头孢噻肟（CTX）敏感（最低抑菌浓度为1微克/毫升或更低），被随机分为三组，分别每6小时、8小时或12小时接受2克CTX治疗。对从患者阳性血培养瓶中获得的细菌沉淀物进行了5小时药敏研究。因此，在血培养中发现革兰阴性菌数小时内就纳入了患者。所有菌血症均得到清除，尽管有2例患者对治疗反应不佳。所有患者的谷值血清杀菌水平均为1:2或更高。本研究支持在选定的革兰阴性菌血症患者中，CTX可以每8小时或12小时使用一次。
