Department of Surgery, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, Republic of Korea.
Department of Hospital Pathology, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, Republic of Korea.
Int J Surg. 2015 Dec;24(Pt A):39-44. doi: 10.1016/j.ijsu.2015.10.031. Epub 2015 Oct 30.
The high mobility group A1 (HMGA1) and high mobility group A2 (HMGA2) proteins are architectural transcription factors that have been implicated in the pathogenesis and progression of multiple malignant tumors, including gastric cancer. The aim of this study was to explore the roles of HMGA1 and HMGA2 in gastric carcinogenesis.
The expression of HMGA1 and HMGA2 was examined in 110 gastric adenocarcinomas, 29 gastric adenomas, and 30 normal controls. The results were correlated with the clinicopathological parameters of the tumors and patient outcome.
The levels of HMGA1 and HMGA2 proteins were significantly increased in gastric cancer samples compared with adenoma and normal gastric tissues. High HMGA1 nuclear immunoreactivity was not correlated with clinicopathological features; however, high levels of HMGA2 protein were significantly associated with T stage, N stage, lymphatic invasion, perineural invasion, and TNM stage. Moreover, HMGA2 expression was significantly associated with shorter recurrence free survival. Multivariate analysis showed that HMGA2 expression was an independent prognostic factor for tumor recurrence.
Our results suggest that HMGA1 and HMGA2 are implicated in gastric carcinogenesis and may play a role in tumor progression towards a more malignant phenotype. The HMGA2 protein may be a useful prognostic marker for predicting tumor recurrence.
高迁移率族蛋白 A1（HMGA1）和高迁移率族蛋白 A2（HMGA2）是结构转录因子，它们与多种恶性肿瘤的发病机制和进展有关，包括胃癌。本研究旨在探讨 HMGA1 和 HMGA2 在胃癌发生中的作用。
检测了 110 例胃腺癌、29 例胃腺瘤和 30 例正常对照组织中 HMGA1 和 HMGA2 的表达。将结果与肿瘤的临床病理参数和患者预后相关联。
与腺瘤和正常胃组织相比，胃癌样本中 HMGA1 和 HMGA2 蛋白水平显著升高。HMGA1 核免疫反应性的高低与临床病理特征无关；然而，HMGA2 蛋白水平与 T 分期、N 分期、淋巴血管侵犯、神经周围侵犯和 TNM 分期显著相关。此外，HMGA2 表达与无复发生存时间显著相关。多因素分析表明，HMGA2 表达是肿瘤复发的独立预后因素。
我们的结果表明，HMGA1 和 HMGA2 参与了胃癌的发生，可能在肿瘤向更恶性表型的进展中起作用。HMGA2 蛋白可能是预测肿瘤复发的有用预后标志物。
