Information Network of Departments of Dermatology, University of Göttingen, 37075, Göttingen, Germany.
Department of Dermatology, University of Essen, 45122, Essen, Germany.
Contact Dermatitis. 2016 Feb;74(2):94-101. doi: 10.1111/cod.12490. Epub 2015 Nov 5.
Beside the basic resins, reactive diluents and hardeners are important sensitizers in epoxy resin systems (ERSs). Because of chemical similarities, immunological cross-reactivity may occur.
To analyse concomitant reactivity among reactive diluents and hardeners in the patients concerned, as one integral part of a research project on the sensitizing capacity of ERSs (FP-0324).
A retrospective analysis of data from the Information Network of Departments of Dermatology (IVDK), 2002-2011, was performed.
There was close concomitant reactivity to 1,6-hexanediol diglycidyl ether and 1,4-butanediol diglycidyl ether (1,4-BDDGE), and to phenyl glycidyl ether (PGE) and cresyl glycidyl ether (CGE), whereas reactions to p-tert-butylphenyl glycidyl ether occurred more independently from those to PGE and CGE. Concomitant reactions to butyl glycidyl ether and 1,4-BDDGE may point to a common allergenic compound derived from the metabolism of 1,4-BDDGE. Among the structurally more diverse group of hardeners, there was no evidence of immunological cross-reactions.
More detailed knowledge of cross-reactivity among ERS components facilitates the interpretation of patch test results and will allow safer ERSs to be composed in the future.
除了基本树脂外，反应性稀释剂和硬化剂也是环氧树脂体系（ERS）中的重要敏化剂。由于化学相似性，可能会发生免疫交叉反应。
分析患者中反应性稀释剂和硬化剂之间的同时反应性，作为对 ERS 致敏能力的研究项目（FP-0324）的一部分。
对 2002 年至 2011 年皮肤科信息网络（IVDK）的数据进行回顾性分析。
1,6-己二醇二缩水甘油醚和 1,4-丁二醇二缩水甘油醚（1,4-BDDGE）之间存在密切的同时反应性，而苯缩水甘油醚（PGE）和甲酚缩水甘油醚（CGE）之间也存在同时反应性，而对 p-叔丁基苯缩水甘油醚的反应则与 PGE 和 CGE 的反应更为独立。丁基缩水甘油醚和 1,4-BDDGE 之间的同时反应可能指向源自 1,4-BDDGE 代谢的共同过敏原化合物。在结构更为多样化的硬化剂组中，没有证据表明存在免疫交叉反应。
对 ERS 成分之间交叉反应性的更详细了解有助于解释斑贴试验结果，并将允许在未来组成更安全的 ERS。
