作为肿瘤细胞迁移抑制剂的迁移他汀类似物的合成：探索大环环内和环上的结构变化

Synthesis of Migrastatin Analogues as Inhibitors of Tumour Cell Migration: Exploring Structural Change in and on the Macrocyclic Ring.

作者信息

Lo Re Daniele, Zhou Ying, Mucha Joanna, Jones Leigh F, Leahy Lorraine, Santocanale Corrado, Krol Magdalena, Murphy Paul V

机构信息

School of Chemistry, National University of Ireland, Galway (Ireland).

Department of Physiological Sciences, Faculty of Veterinary Medicine, Warsaw University of Life Science, Warsaw (Poland).

出版信息

Chemistry. 2015 Dec 7;21(50):17993. doi: 10.1002/chem.201504167. Epub 2015 Nov 5.

DOI:10.1002/chem.201504167

PMID:26537992

Abstract

Invited for the cover of this issue are Paul V. Murphy and co-workers at the National University of Ireland Galway (NUI Galway) and Warsaw University. The image depicts MGSTA-6 giving a stop signal to tumour cells that are on the move. Read the full text of the article at 10.1002/chem.201502861.

摘要

本期的封面受邀之作是爱尔兰国立高威大学（NUI高威）和华沙大学的保罗·V·墨菲及其同事的研究成果。该图片描绘了MGSTA - 6向正在移动的肿瘤细胞发出停止信号的情景。可在10.1002/chem.201502861阅读该文章的全文。