Eladl Ahmed E, Satou Akira, Elsayed Ahmed Ali, Suzuki Yuka, Shimizu-Kohno Kei, Kato Seiichi, Tomita Akihiro, Kinoshita Tomohiro, Nakamura Shigeo, Asano Naoko
Department of Pathology and Laboratory Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Department of Pathology, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
Pathol Int. 2015 Dec;65(12):652-60. doi: 10.1111/pin.12357. Epub 2015 Nov 5.
Clinicopathological features of 25 nodular lymphocyte predominant Hodgkin lymphoma (NLPHL) patients in Japan were analysed. To investigate the clinicopathological significance of tissue associated macrophages (TAM) in NLPHL, CD68 and CD163 expression were investigated. The median age at onset was 56 years (range: 6-82 years) with male predominance (64%). All patients presented with lymph node enlargement with predilection for cervical LNs. Seven cases (28%) had mediastinal lesion and four (16%) had extranodal involvement. Most cases (76%) presented with early clinical stages. After median follow up of 44 months, both of overall and progression free survival rates were 95%. The presence of >5% CD68+ TAM in NLPHL was significantly associated with older age at diagnosis (median, 71 vs 52.5 years; P = 0.048), lower hemoglobin level (33.3% vs 0%; P = 0.037) and lower CR rate after initial treatment (42.9% vs 91.7%; P = 0.038). The presence of >5% CD163+ TAM was significantly correlated with presence of B symptoms (40% vs 0%; P = 0.036). In conclusion, NLPHL is rare among Japanese and appears to present at an older age than among Western patients. In our series, the presence of >5% CD68+ TAM in NLPHL was associated with lower CR rate, but with no impact on patients' survival.
分析了25例日本结节性淋巴细胞为主型霍奇金淋巴瘤（NLPHL）患者的临床病理特征。为了研究NLPHL中组织相关巨噬细胞（TAM）的临床病理意义，对CD68和CD163的表达进行了研究。发病年龄中位数为56岁（范围：6 - 82岁），以男性为主（64%）。所有患者均表现为淋巴结肿大，以颈部淋巴结为主。7例（28%）有纵隔病变，4例（16%）有结外受累。大多数病例（76%）处于临床早期。中位随访44个月后，总生存率和无进展生存率均为95%。NLPHL中CD68 + TAM>5%与诊断时年龄较大（中位数，71岁对52.5岁；P = 0.048）、血红蛋白水平较低（33.3%对0%；P = 0.037）以及初始治疗后较低的完全缓解率（42.9%对91.7%；P = 0.038）显著相关。CD163 + TAM>5%的存在与B症状的存在显著相关（40%对0%；P = 0.036）。总之，NLPHL在日本人中罕见，且发病年龄似乎比西方患者大。在我们的系列研究中，NLPHL中CD68 + TAM>5%与较低的完全缓解率相关，但对患者生存无影响。
