小儿实体器官移植受者艰难梭菌感染的结局
Outcomes of Clostridium difficile infection in pediatric solid organ transplant recipients.
作者信息
Pant C, Deshpande A, Desai M, Jani B S, Sferra T J, Gilroy R, Olyaee M
机构信息
Division of Gastroenterology, Hepatology and Motility, Department of Internal Medicine, University of Kansas Medical Center, Kansas City, Kansas, USA.
Medicine Institute Center for Value Based Care, Cleveland Clinic, Cleveland, Ohio, USA.
出版信息
Transpl Infect Dis. 2016 Feb;18(1):31-6. doi: 10.1111/tid.12477. Epub 2016 Jan 30.
BACKGROUND
The incidence of Clostridium difficile infection (CDI) is increasing in the pediatric population. Pediatric recipients of solid organ transplantation (SOT) may be at a higher risk for CDI in part because of chemotherapy and prolonged hospitalization.
METHODS
We utilized data from the Healthcare Cost and Utilization Project Kids' Inpatient Database to study the incidence and outcomes related to CDI as a complicating factor in pediatric recipients of SOT.
RESULTS
Our results demonstrate that hospitalized children with SOT have increased rates of infection, with the greatest risk for younger children with additional comorbidities and severe illness. The type of transplanted organ affects the risk for CDI, with the lowest incidence observed in renal transplant patients.
CONCLUSION
The occurrence of CDI in the pediatric SOT population contributes to a greater length of stay and higher hospital charges. However, CDI is not an independent predictor of increased in- hospital mortality in these patients.
背景
艰难梭菌感染（CDI）在儿科人群中的发病率正在上升。实体器官移植（SOT）的儿科受者可能因化疗和长期住院而面临更高的CDI风险。
方法
我们利用医疗保健成本和利用项目儿童住院数据库的数据，研究CDI作为SOT儿科受者的一个复杂因素的发病率和结局。
结果
我们的结果表明，住院的SOT儿童感染率增加，合并其他疾病和患有严重疾病的年幼儿童风险最高。移植器官的类型影响CDI风险，肾移植患者的发病率最低。
结论
儿科SOT人群中CDI的发生导致住院时间延长和医院费用增加。然而，CDI并不是这些患者住院死亡率增加的独立预测因素。
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