Antonara Stella, Leber Amy L
Nationwide Children's Hospital, Department of Laboratory Medicine, Columbus, Ohio, USA
Nationwide Children's Hospital, Department of Laboratory Medicine, Columbus, Ohio, USA.
J Clin Microbiol. 2016 Jun;54(6):1425-1433. doi: 10.1128/JCM.03014-15. Epub 2016 Feb 24.
The detection and diagnosis of Clostridium difficile infection in pediatric populations have some unique considerations in comparison to testing in adults. The testing methodologies, including toxigenic culture, cell cytotoxicity, antigen detection, and, more recently, molecular testing, are the same in all age groups. However, limited data exist on the specific performance characteristics in children. In this review, we focus on the challenges of testing in pediatric populations and assess the available data on test performance in these populations. Additionally, a review of the existing guidance for testing is provided.
与成人检测相比，儿科人群中艰难梭菌感染的检测和诊断有一些独特的考量因素。包括产毒培养、细胞毒性、抗原检测以及最近的分子检测在内的检测方法在所有年龄组中都是相同的。然而，关于儿童的具体性能特征的数据有限。在本综述中，我们关注儿科人群检测的挑战，并评估这些人群中检测性能的现有数据。此外，还提供了对现有检测指南的综述。
