Brain S D
Section of Vascular Biology, MRC Clinical Research Centre, Harrow, Middlesex, U.K.
Eur J Pharmacol. 1989 Feb 7;160(3):401-3. doi: 10.1016/0014-2999(89)90096-4.
The effect of endothelin on the microvasculature of the hamster cheek pouch was observed directly using intravital microscopy. Endothelin caused a dose-dependent arteriolar constriction without affecting adjacent venules. Endothelin was less potent than vasopressin, but responses to endothelin were longer lasting (48.9 +/- 11.1% reduction in arteriolar diameter was still observed 30 min after topical application of 3 pmol endothelin). The results demonstrate that endothelin induces a prolonged increase in local arteriolar tone after a single application in vivo.
采用活体显微镜直接观察内皮素对仓鼠颊囊微血管的影响。内皮素引起剂量依赖性小动脉收缩，而不影响相邻的小静脉。内皮素的作用效力低于血管加压素，但对内皮素的反应持续时间更长（局部应用3 pmol内皮素30分钟后，仍可观察到小动脉直径缩小48.9±11.1%）。结果表明，内皮素在体内单次应用后可诱导局部小动脉张力长期升高。
