Lakshmi Chembolli, Swarnalakshimi Selvaraj
Department of Dermatology, PSG Hospitals and PSG Institute of Medical Sciences and Research, Coimbatore, Tamil Nadu, India.
Indian J Dermatol. 2015 Sep-Oct;60(5):494-6. doi: 10.4103/0019-5154.164373.
Klinefelter syndrome (KFS) is the most common non-heritable sex chromosome anomaly caused by nondisjunction during cell division and contains two or more X chromosomes. More than two third of all cases are homogenous (47XXY) and the remaining are mosaic (46XY/47XXY). Lower limb ulcers are frequently observed and attributed to impaired fibrinolysis. A case of KFS with post acne scars and leg ulcers is presented. The rarity of acne in this syndrome is explained by the phenomenon of mosaicism.
克兰费尔特综合征（KFS）是最常见的非遗传性性染色体异常疾病，由细胞分裂过程中的不分离现象引起，含有两条或更多条X染色体。所有病例中超过三分之二为均质型（47XXY），其余为嵌合型（46XY/47XXY）。下肢溃疡较为常见，原因是纤维蛋白溶解功能受损。本文报告了一例患有痤疮后瘢痕和腿部溃疡的克兰费尔特综合征病例。该综合征中痤疮罕见可由嵌合现象来解释。
