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伴有高同型半胱氨酸血症的萎缩性血管病对高压氧治疗有效。

Livedoid Vasculopathy with Hyperhomocysteinemia Responding to Hyperbaric Oxygen Therapy.

作者信息

Ray Rahul, Sharma Aseem, Vasudevan Biju, Sridhar Jandhyala, Deo Rajeev, Mohanty C S

机构信息

Department of Dermatology, INHS Asvini, Mumbai, Maharashtra, India.

Department of Marine Medicine, INHS Asvini, Mumbai, Maharashtra, India.

出版信息

Indian J Dermatol. 2015 Sep-Oct;60(5):524. doi: 10.4103/0019-5154.159657.

Abstract

A 30-year-old male presented to the dermatology department with complaints of multiple ulcers over both legs of 6 years duration. The ulcers had a waxing and waning course with present exacerbation of lesions since 1 month. Dermatological examination revealed multiple ulcers distributed in a reticular pattern over medial and lateral aspects of both lower legs, extensor aspect of both ankles and dorsum of both feet. Multiple interspersed atrophic porcelain white scars were also present. Investigations revealed raised serum homocysteine levels. A skin biopsy from the ulcers showed features of livedoid vasculopathy. Following recurrence of lesions after oral corticosteroid therapy, the patient was given a course of hyperbaric oxygen therapy for the ulcers to which he responded very well. This case is being presented for the novel option of hyperbaric oxygen therapy in livedoid vasculopathy, which by itself is rarely reported in this part of the world.

摘要

一名30岁男性因双下肢出现多处溃疡6年就诊于皮肤科。溃疡病情呈反复消长,近1个月病情加重。皮肤科检查发现多处溃疡呈网状分布于双小腿内、外侧,双踝伸侧及双足背。还存在多处散在的萎缩性瓷白色瘢痕。检查发现血清同型半胱氨酸水平升高。溃疡部位的皮肤活检显示有类脂质渐进性坏死性血管病的特征。口服糖皮质激素治疗后病变复发,随后该患者接受了一个疗程的高压氧治疗溃疡,效果良好。本文报告此病例是为了介绍高压氧治疗类脂质渐进性坏死性血管病这一新颖的治疗方法,而在世界的这一地区,此类报道本身很少见。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/35bc/4601462/6e658d88cc7f/IJD-60-524b-g001.jpg

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