Szkudlinski Mariusz W
Trophogen Inc. , Rockville, MD , USA.
Front Endocrinol (Lausanne). 2015 Oct 19;6:155. doi: 10.3389/fendo.2015.00155. eCollection 2015.
Last two decades of structure-function studies performed in numerous laboratories provided substantial progress in understanding basic science, physiological, pathophysiological, pharmacological, and comparative aspects of glycoprotein hormones (GPHs) and their cognate receptors. Multiple concepts and models developed based on experimental data in the past stood the test of time and have been, at least in part, confirmed and/or remained compatible with the new structures resolved at the atomic level. Major advances in understanding of the ligand-receptor relationships are heralding the dawn of a new era for GPHs and their receptors, although many basic questions still remain unanswered. This article examines retrospectively several basic science aspects of GPH super-agonists and related "biosuperiors" in a broader context of the advances in the ligand-receptor structure-function relationships and new mechanistic models generated based on the structure elucidation. Due to selective focus of my comments and perspectives in certain parts, the reader is directed to the most relevant publications and reviews in the field for more comprehensive analyses.
在众多实验室进行的关于结构-功能研究的过去二十年，在理解糖蛋白激素（GPHs）及其同源受体的基础科学、生理学、病理生理学、药理学和比较方面取得了重大进展。过去基于实验数据发展的多个概念和模型经受住了时间的考验，并且至少在部分程度上得到了证实和/或与在原子水平解析的新结构保持一致。尽管许多基本问题仍然没有答案，但在理解配体-受体关系方面的重大进展预示着GPHs及其受体新时代的来临。本文在配体-受体结构-功能关系进展以及基于结构阐明产生的新机制模型的更广泛背景下，回顾性地研究了GPH超级激动剂和相关“生物优势物”的几个基础科学方面。由于我在某些部分的评论和观点具有选择性重点，因此引导读者参考该领域最相关的出版物和综述以进行更全面的分析。
