Department of Mechanical and Industrial Engineering, Ryerson University, Toronto M5B 2K3, Canada.
Department of Aerospace Engineering, Ryerson University, Toronto M5B 2K3, Canada.
Colloids Surf B Biointerfaces. 2015 Dec 1;136:828-37. doi: 10.1016/j.colsurfb.2015.10.007. Epub 2015 Oct 26.
We introduce a hybrid nanostructured biomaterial that is a combination of rare phases of immiscible gold and silicon oxide, functionalized via ultrafast laser synthesis. For the first time, we show cancer controlling properties of rare phases of gold silicides, which include Au7Si, Au5Si, Au0.7Si2.3 and Au8Si2. Conventionally, pure forms of gold and silicon/silicon oxide are extensively employed in targeted therapy and drug delivery systems due to their unique properties. While silicon and silicon oxide nanoparticles have shown biocompatibility, gold nanoparticles show conflicting results based on their size and material properties. Several studies have shown that gold and silicon combinations produce cell controlling properties, however, these studies were not able to produce a homogenous combination of gold and silicon, owing to its immiscibility. A homogenous combination of gold and silicon may potentially enable properties that have not previously been reported. We describe rare phased gold-silicon oxide nanostructured hybrid biomaterials and its unique cancer controlling properties, owing to material properties, concentration, size and density. The gold-silicon oxide nanostructured hybrid is composed of individual gold-silicon oxide nanoparticles in various concentrations of gold and silicon, some nanoparticles possess a gold-core and silicon-shell like structure. The individual nanoparticles are bonded together forming a three dimensional nanostructured hybrid. The interaction of the nanostructured hybrids with cervical cancer cells showed a 96% reduction in 24h. This engineered nanostructured hybrid biomaterial presents significant potential due to the combination of immiscible gold and silicon oxide in varying phases and can potentially satiate the current vacuum in cancer therapy.
我们介绍了一种混合纳米结构生物材料，它是不混溶的金和氧化硅的稀有相的组合，通过超快激光合成功能化。我们首次展示了金硅化物稀有相的抗癌特性，包括 Au7Si、Au5Si、Au0.7Si2.3 和 Au8Si2。传统上，由于其独特的性质，纯金和硅/氧化硅被广泛应用于靶向治疗和药物输送系统。虽然硅和氧化硅纳米粒子表现出生物相容性，但金纳米粒子的生物相容性则基于其尺寸和材料特性而存在争议。多项研究表明，金和硅的组合产生了细胞控制特性，但这些研究由于其不混溶性，无法产生金和硅的均匀混合物。金和硅的均匀混合物可能具有以前未报道过的特性。我们描述了稀有相金-氧化硅纳米结构混合生物材料及其独特的抗癌特性，这归因于材料特性、浓度、尺寸和密度。金-氧化硅纳米结构混合由各种浓度的金和硅的单个金-氧化硅纳米粒子组成，一些纳米粒子具有金核和硅壳的类似结构。单个纳米粒子结合在一起形成三维纳米结构混合体。纳米结构混合体与宫颈癌细胞的相互作用在 24 小时内降低了 96%。由于不混溶的金和氧化硅在不同相中结合，这种工程化的纳米结构混合生物材料具有显著的潜力，并可能满足癌症治疗的当前需求。
