纳米颗粒形态和酰基链长度对自发脂质转移速率的影响。
Effects of Nanoparticle Morphology and Acyl Chain Length on Spontaneous Lipid Transfer Rates.
作者信息
Xia Yan, Li Ming, Charubin Kamil, Liu Ying, Heberle Frederick A, Katsaras John, Jing Benxin, Zhu Yingxi, Nieh Mu-Ping
机构信息
Department of Chemical and Biomolecular Engineering, University of Connecticut , Storrs, Connecticut 06269, United States.
Polymer Program, Institute of Materials Science, University of Connecticut , Storrs, Connecticut 06269, United States.
出版信息
Langmuir. 2015 Dec 1;31(47):12920-8. doi: 10.1021/acs.langmuir.5b03291. Epub 2015 Nov 19.
We report on studies of lipid transfer rates between different morphology nanoparticles and lipids with different length acyl chains. The lipid transfer rate of dimyristoylphosphatidylcholine (di-C14, DMPC) in discoidal "bicelles" (0.156 h(-1)) is 2 orders of magnitude greater than that of DMPC vesicles (ULVs) (1.1 × 10(-3) h(-1)). For both bicellar and ULV morphologies, increasing the acyl chain length by two carbons [going from di-C14 DMPC to di-C16, dipalmitoylphosphatidylcholine (DPPC)] causes lipid transfer rates to decrease by more than 2 orders of magnitude. Results from small angle neutron scattering (SANS), differential scanning calorimetry (DSC), and fluorescence correlation spectroscopy (FCS) are in good agreement. The present studies highlight the importance of lipid dynamic processes taking place in different morphology biomimetic membranes.
我们报告了关于不同形态纳米颗粒与具有不同长度酰基链的脂质之间脂质转移速率的研究。二肉豆蔻酰磷脂酰胆碱（di-C14，DMPC）在盘状“双分子层”（0.156 h⁻¹）中的脂质转移速率比DMPC囊泡（超大单层囊泡，ULVs）（1.1×10⁻³ h⁻¹）的脂质转移速率高2个数量级。对于双分子层和ULV形态，将酰基链长度增加两个碳原子[从di-C14 DMPC变为di-C16，二棕榈酰磷脂酰胆碱（DPPC）]会导致脂质转移速率降低超过2个数量级。小角中子散射（SANS）、差示扫描量热法（DSC）和荧光相关光谱法（FCS）的结果高度一致。本研究突出了在不同形态仿生膜中发生的脂质动态过程的重要性。
Zotero 插件