Lee Kang Pa, Choi Nan Hee, Sudjarwo Giftania Wardani, Ahn Sang-Hyun, Park In-Sik, Lee Sang-Rak, Hong Heeok
1 Department of Medical Science, School of Medicine, Konkuk University , Gwangjin-gu, Seoul, Korea.
2 Department of Anatomy, College of Korean Medicine, Dongguk University , Gyeongju, Korea.
J Med Food. 2016 Feb;19(2):127-32. doi: 10.1089/jmf.2015.3476. Epub 2015 Nov 5.
Gastric ulcer is a common digestive disorder that results in considerable suffering. Hence, this digestive pathology has been the focus of a number of recent studies. Although numerous drugs have been developed to treat gastric ulcers, therapeutic approaches for many of the complications associated with these drugs remain to be identified. For this reason, many natural compounds have been explored as alternatives for these drugs. In this study, we have investigated the effectiveness of Areca catechu leaf ethanol extract (ACE) for treating ethanol-induced gastric ulcers in mice. We performed histological as well as immunohistochemical examinations to explore the therapeutic properties of ACE. We also examined the levels of inflammatory signaling molecules to confirm the anti-inflammatory effects of ACE. The histochemical data demonstrate that ACE can protect the mucosal epithelium as well as the vascular supply in the gastric tract. Furthermore, ACE significantly reduced the expression levels of tumor necrosis factor-alpha (TNF-α), interleukin-6 receptor (IL-6R), inducible NO synthase (iNOS), cyclooxygenase 2 (COX2), and nuclear factor-kappa B (NF-κB). Taken together, these data suggest that ACE administration may have the potential as an alternative treatment for gastric ulcer because of its cytoprotective and anti-inflammatory effects and ability to promote the rejuvenation and revascularization of the damaged gastric epithelium.
胃溃疡是一种常见的消化系统疾病，会带来巨大痛苦。因此，这种消化系统病理学一直是近期多项研究的重点。尽管已经开发出许多药物来治疗胃溃疡，但与这些药物相关的许多并发症的治疗方法仍有待确定。出于这个原因，人们探索了许多天然化合物作为这些药物的替代品。在本研究中，我们研究了槟榔叶乙醇提取物（ACE）对治疗小鼠乙醇诱导的胃溃疡的有效性。我们进行了组织学和免疫组织化学检查，以探索ACE的治疗特性。我们还检测了炎症信号分子的水平，以证实ACE的抗炎作用。组织化学数据表明，ACE可以保护胃黏膜上皮以及胃血管供应。此外，ACE显著降低了肿瘤坏死因子-α（TNF-α）、白细胞介素-6受体（IL-6R）、诱导型一氧化氮合酶（iNOS）、环氧化酶2（COX2）和核因子-κB（NF-κB）的表达水平。综上所述，这些数据表明，由于ACE具有细胞保护和抗炎作用以及促进受损胃上皮细胞再生和血管生成的能力，给予ACE可能有作为胃溃疡替代治疗的潜力。
