Girdlestone Christopher, Hayward Steven
D'Arcy Thompson Centre for Computational Biology, School of Computing Sciences, University of East Anglia , Norwich, United Kingdom .
J Comput Biol. 2016 Jan;23(1):21-6. doi: 10.1089/cmb.2015.0143. Epub 2015 Nov 5.
DynDom3D is a program for the analysis of domain movements in multimeric proteins. Its inputs are two structure files that indicate a possible domain movement, but the onus has been on the user to process the files so that there is the necessary one-to-one equivalence between atoms in the two atom lists. This is often a prohibitive task to carry out manually, which has limited the application of DynDom3D. Here we report on a webserver with a preprocessor that automatically creates an equivalence between atoms using sequence alignment methods. The processed structure files are passed to DynDom3D and the results are presented on a webpage that includes molecular graphics for easy visualization.
DynDom3D是一个用于分析多聚体蛋白中结构域运动的程序。其输入是两个表示可能的结构域运动的结构文件，但用户有责任处理这些文件，以便两个原子列表中的原子之间存在必要的一一对应关系。这通常是一项难以手动完成的任务，这限制了DynDom3D的应用。在此，我们报告一个带有预处理器的网络服务器，该预处理器使用序列比对方法自动创建原子之间的对应关系。处理后的结构文件被传递给DynDom3D，结果会在一个包含分子图形以便于可视化的网页上呈现。
