Masaoka Kosuke, Asato Hirotaka, Umekawa Kohei, Imanishi Masaya, Suzuki Ayako
a Department of Plastic and Reconstructive Surgery , Dokkyo Medical University , Shimotsuga, Tochigi , Japan.
J Plast Surg Hand Surg. 2016;50(2):107-10. doi: 10.3109/2000656X.2015.1106410. Epub 2015 Nov 5.
According to previous reports, remote ischaemic preconditioning (RIPC) is a "delay" procedure that is highly likely to be useful for preventing skin flap necrosis. Differences in the extent of necrosis in rat dorsal skin flaps when different clamping times were used in RIPC were compared among the four groups described below.
Group A was a control group in which no prior ischaemic area was created, and both back legs were devascularised for 15 min in Group B, 30 min in Group C, and 60 min in Group D. The experiments were performed on 10 rats in each group, and the surviving area was measured. One-way analysis of variance (ANOVA) and Tukey's multiple comparison test were used for analysis, with p < 0.05 regarded as significant.
The surviving area of the skin flap was 15.4 ± 1.8 cm(2) in Group A, 15.4 ± 2.0 cm(2) in Group B, 17.9 ± 2.0 cm(2) in Group C, and 19.2 ± 3.4 cm(2) in Group D, with significant differences between Groups A and D and between Groups B and D.
RIPC consisting of 60 min of ischaemic preconditioning may be clinically useful as a method of preventing skin flap necrosis.
根据先前的报道，远程缺血预处理（RIPC）是一种“延迟”程序，极有可能有助于预防皮瓣坏死。在以下四组中比较了在RIPC中使用不同夹闭时间时大鼠背部皮瓣坏死程度的差异。
A组为对照组，未创建先前的缺血区域，B组双后肢去血管化15分钟，C组30分钟，D组60分钟。每组对10只大鼠进行实验，并测量存活面积。采用单因素方差分析（ANOVA）和Tukey多重比较检验进行分析，p < 0.05认为具有显著性。
A组皮瓣存活面积为15.4±1.8cm²，B组为15.4±2.0cm²，C组为17.9±2.0cm²，D组为19.2±3.4cm²，A组与D组之间以及B组与D组之间存在显著差异。
由60分钟缺血预处理组成的RIPC作为预防皮瓣坏死的方法可能在临床上有用。
