Happle R
Dermatologische Klinik, Universität Nijmegen.
Hautarzt. 1989 Feb;40(2):70-6.
In contrast to what has so far generally been believed, dysplastic nevi do not appear to be mendelizing, but rather due to polygenic inheritance. In order to explain this contrasting idea, the following six theses are presented: (1) All dysplastic nevi are inherited in the same manner. (2) Dysplastic nevi constitute a continuous trait. (3) A "dysplastic nevus syndrome" in the form of a monogenic autosomal dominant trait probably does not exist. (4) A nonhereditary dysplastic nevus syndrome does not exist. (5) The number of the underlying genes that, considered separately, do of course follow the rules of mendelian inheritance is so far unknown. (6) A search for a single underlying gene defect is probably hopeless.
与目前普遍认为的情况相反，发育异常痣似乎并非孟德尔式遗传，而是由多基因遗传所致。为解释这一不同观点，现提出以下六个论点：（1）所有发育异常痣均以相同方式遗传。（2）发育异常痣构成一种连续性性状。（3）可能不存在单基因常染色体显性性状形式的“发育异常痣综合征”。（4）不存在非遗传性发育异常痣综合征。（5）目前尚不清楚单独来看当然遵循孟德尔遗传规律的潜在基因数量。（6）寻找单一潜在基因缺陷可能毫无希望。
