信号素4A作为类风湿关节炎的新型调节因子和有前景的治疗靶点。
Semaphorin 4A as novel regulator and promising therapeutic target in rheumatoid arthritis.
作者信息
Chapoval Svetlana P
机构信息
SemaPlex LLC, 3632 Chateau Ridge Drive, Ellicott City, MD, 21042, USA.
Department of Microbiology and Immunology, Center for Vascular and Inflammatory Diseases, University of Maryland School of Medicine, 800 West Baltimore Street, Room 301, Baltimore, MD, 21012, USA.
出版信息
Arthritis Res Ther. 2015 Nov 6;17:313. doi: 10.1186/s13075-015-0846-4.
Rheumatoid arthritis (RA) is a systemic autoimmune disease manifesting in joint destruction. The recognized hallmark of RA pathogenesis is the involvement of immune cells which produce many mediators potentiating an inflammatory environment. RA synovial fibroblasts (RASFs) contribute significantly to disease progression by initiating and regulating many pathways of joint destruction. Detailed molecular insights into RASF biology may lead to identification of important therapeutic targets. The discovery of common molecular targets for joint resident and inflammatory cells may help to develop the most effective therapeutic strategy. One such pathway includes semaphorin 4A as reported in a recent article in Arthritis Research & Therapy.
类风湿性关节炎（RA）是一种表现为关节破坏的全身性自身免疫性疾病。RA发病机制的公认标志是免疫细胞的参与，这些免疫细胞产生许多促进炎症环境的介质。RA滑膜成纤维细胞（RASF）通过启动和调节许多关节破坏途径，对疾病进展有显著贡献。对RASF生物学的详细分子洞察可能会导致识别重要的治疗靶点。发现关节驻留细胞和炎症细胞的共同分子靶点可能有助于制定最有效的治疗策略。正如《关节炎研究与治疗》最近一篇文章所报道的，其中一条这样的途径包括信号素4A。
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