通过功能磁共振成像评估人类脊髓的伤害感受：一项系统综述。
Assessing Nociception by fMRI of the Human Spinal Cord: A Systematic Review.
作者信息
Kolesar Tiffany A, Fiest Kirsten M, Smith Stephen D, Kornelsen Jennifer
机构信息
Department of Psychology, University of Winnipeg, Manitoba, Canada.
Department of Internal Medicine, University of Manitoba, Manitoba, Canada.
出版信息
Magn Reson Insights. 2015 Oct 27;8(Suppl 1):31-9. doi: 10.4137/MRI.S23556. eCollection 2015.
OBJECTIVE
To assess the use of fMRI of the spinal cord in measuring noxious stimulation.
METHODS
The Scopus, Medline, EMBASE, and Web of Science databases were searched, along with the reference lists of included articles. Two independent reviewers screened abstracts, full-text articles, and extracted data. Original research was included if fMRI of the human spinal cord was used to measure responses to noxious stimulation.
RESULTS
Of the 192 abstracts screened, 19 met the search criteria and were divided according to their focus: investigating pain responses (n = 6), methodology (n = 6), spinal cord injury (n = 2), or cognition-pain interactions (n = 5). All but one study appear to have observed activity in ipsilateral and dorsal gray matter regions in response to noxious stimuli, although contralateral or ventral activity was also widely observed.
CONCLUSIONS
Although nociception can be investigated using spinal fMRI, establishing reliability, standardizing methodology, and reporting of results will greatly advance this field.
目的
评估脊髓功能磁共振成像（fMRI）在测量伤害性刺激中的应用。
方法
检索了Scopus、Medline、EMBASE和Web of Science数据库以及纳入文章的参考文献列表。两名独立评审员筛选摘要、全文文章并提取数据。如果使用人类脊髓功能磁共振成像来测量对伤害性刺激的反应，则纳入原始研究。
结果
在筛选的192篇摘要中，19篇符合检索标准，并根据其重点进行了分类：研究疼痛反应（n = 6）、方法学（n = 6）、脊髓损伤（n = 2）或认知-疼痛相互作用（n = 5）。除一项研究外，所有研究似乎都观察到了同侧和背侧灰质区域对伤害性刺激的反应活动，尽管对侧或腹侧活动也被广泛观察到。
结论
虽然可以使用脊髓功能磁共振成像来研究伤害感受，但建立可靠性、规范方法学和结果报告将极大地推动该领域的发展。
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