Malkan Umit Yavuz, Gunes Gursel, Corakci Ahmet
Department of Internal Medicine, School of Medicine, Ufuk University, Ankara, Turkey.
Department of Endocrinology, School of Medicine, Ufuk University, Ankara, Turkey.
Springerplus. 2015 Oct 9;4:587. doi: 10.1186/s40064-015-1389-5. eCollection 2015.
Diabetes mellitus (DM) is a frequently encountered disease with important morbidity and mortality. The aim of this study is to document the importance of 1,5-anhydroglucitol (1,5-AG) for the diagnosis of prediabetes and DM, as well as to compare the 1,5-AG with other glycemic markers in order to understand which one is the better diagnostic tool. Between April 2012 and December 2012, 128 participants enrolled in the study. Participants were split into five groups that are IFG, IGT, IFG+IGT, diabetic and control groups by their OGTT results. The diagnostic value of markers was compared by ROC (receiver operating characteristic) method. The mean serum 1,5-AG levels in the diabetic group (33.38 nmol/ml) were lower than, IFG (59.83 nmol/ml), IGT (54.44 nmol/ml), IFG+IGT (51.98 nmol/ml) and control groups (73.24 nmol/ml). When analyzed in the total study population serum 1,5-AG levels did not differ by gender significantly. When analyzed in the total study population, 1,5-AG correlates inversely with age significantly (p = 0.036). In subgroup analysis, in the control group, serum 1,5-AG level was also inversely correlated with age (p = 0.087). The best marker for the diagnosis of prediabetes and DM was fasting plasma glucose (FPG). 1,5-AG was not found to be effective for the diagnosis of DM. This study, contributes to our knowledge of the efficiency and cut-off values of 1,5-AG for the diagnosis of prediabetes and DM. In future, there is a need for larger studies with more standardized and commonly used measurement methods for 1,5-AG, in order to evaluate the efficiency of 1,5-AG for the diagnosis of prediabetes and DM.
糖尿病（DM）是一种常见疾病，具有重要的发病率和死亡率。本研究的目的是记录1,5-脱水葡萄糖醇（1,5-AG）在糖尿病前期和糖尿病诊断中的重要性，并将1,5-AG与其他血糖标志物进行比较，以了解哪一种是更好的诊断工具。在2012年4月至2012年12月期间，128名参与者纳入了该研究。根据口服葡萄糖耐量试验（OGTT）结果，参与者被分为空腹血糖受损（IFG）、糖耐量受损（IGT）、IFG+IGT、糖尿病和对照组五组。通过ROC（受试者工作特征）方法比较标志物的诊断价值。糖尿病组的平均血清1,5-AG水平（33.38 nmol/ml）低于IFG组（59.83 nmol/ml）、IGT组（54.44 nmol/ml）、IFG+IGT组（51.98 nmol/ml）和对照组（73.24 nmol/ml）。在总研究人群中进行分析时，血清1,5-AG水平在性别上无显著差异。在总研究人群中进行分析时，1,5-AG与年龄呈显著负相关（p = 0.036）。在亚组分析中，对照组的血清1,5-AG水平也与年龄呈负相关（p = 0.087）。糖尿病前期和糖尿病诊断的最佳标志物是空腹血糖（FPG）。未发现1,5-AG对糖尿病诊断有效。本研究有助于我们了解1,5-AG在糖尿病前期和糖尿病诊断中的效率及临界值。未来，需要进行更大规模的研究，采用更标准化和常用的1,5-AG测量方法，以评估1,5-AG在糖尿病前期和糖尿病诊断中的效率。
