Breyer Freitas Bruna, Rothen Renata Elisabeth, Zeni Débora, Garcia Soares Leães Carolina, Costa Oliveira Miriam, Michielin Busnello Fernanda, Fernanda Semmelmann Pereira-Lima Júlia
Federal University of Health Sciences of Porto Alegre (UFCSPA)..
Neuroendocrinology Center of Santa Casa of Porto Alegre, Federal University of Health Sciences of Porto Alegre (UFCSPA), Porto Alegre..
Nutr Hosp. 2015 Nov 1;32(5):2030-7. doi: 10.3305/nh.2015.32.5.9673.
prolactinomas are pituitary adenomas that express and secrete prolactin. These patients are overweight and the mechanisms are being studied.
assess nutritional and metabolic status of overweight patients with and without hyperprolactinemia caused by prolactinoma and compare them.
cross-sectional study, patients with body mass index (BMI) ≥ 25 kg/m2 with and without prolactinoma: 1) 20 normoprolactinemic (NPrl) with prolactinoma; 2) 23 hyperprolactinemic (HPrl) with prolactinoma; 3) 28 controls without prolactinoma or alterations in prolactin levels. Evaluated through anthropometric, dietetics, and biochemical assessment.
of the 71 patients evaluated, most were obese women with macroprolactinomas. All three groups had diets with low caloric and monounsaturated fatty acid (MUFA) intake, the NPrl group had low carbohydrate (CHO) intake and high lipid (LIP) and saturated fatty acid (SFA) intake, and the NPrl and HPrl groups had appropriate intake of polyunsaturated fatty acids (PUFA). The HPrl group had elevated total cholesterol. HDL cholesterol was below the recommended threshold for most patients. No statistically significant differences were found in anthropometric and biochemical variables among the groups.
most patients with prolactinomas and controls are obese and metabolically similar regardless of prolactin levels. All groups presented low caloric and MUFA intake. Protein, LIP, SFA, and cholesterol were significantly different among the groups, the NPrl group ingested less amount of protein and greater of fat. Snacking between meals and changes of food consumption on weekends was reported by most patients. This is the first study comparing patients with prolactinomas and controls, both with overweight, regarding food consumption and feeding behavior.
催乳素瘤是表达和分泌催乳素的垂体腺瘤。这些患者超重，其机制正在研究中。
评估患有和未患有由催乳素瘤引起的高催乳素血症的超重患者的营养和代谢状况，并进行比较。
横断面研究，体重指数（BMI）≥25 kg/m²的患有和未患有催乳素瘤的患者：1）20例催乳素正常（NPrl）的催乳素瘤患者；2）23例高催乳素血症（HPrl）的催乳素瘤患者；3）28例无催乳素瘤或催乳素水平无改变的对照者。通过人体测量、饮食学和生化评估进行评价。
在评估的71例患者中，大多数是患有大催乳素瘤的肥胖女性。所有三组的饮食热量和单不饱和脂肪酸（MUFA）摄入量均较低，NPrl组碳水化合物（CHO）摄入量低，脂质（LIP）和饱和脂肪酸（SFA）摄入量高，NPrl组和HPrl组多不饱和脂肪酸（PUFA）摄入量适宜。HPrl组总胆固醇升高。大多数患者的高密度脂蛋白胆固醇低于推荐阈值。各组之间在人体测量和生化变量方面未发现统计学上的显著差异。
大多数催乳素瘤患者和对照者均肥胖，且无论催乳素水平如何，代谢情况相似。所有组的热量和MUFA摄入量均较低。各组之间蛋白质、LIP、SFA和胆固醇存在显著差异，NPrl组摄入的蛋白质较少，脂肪较多。大多数患者报告有餐间吃零食和周末食物消费变化的情况。这是第一项比较超重的催乳素瘤患者和对照者在食物消费和进食行为方面的研究。
