[豇豆肽片段对血管紧张素转换酶-I的体外抑制作用、降压及抗高血压作用研究]
[STUDIES IN VITRO INHIBITION OF THE ANGIOTENSIN-CONVERTING ENZYME-I, HYPOTENSIVE AND ANTIHYPERTENSIVE EFFECTS OF PEPTIDE FRACTIONS OF V. UNGUICULATA].
作者信息
Cú-Cañetas Trinidad, Betancur Ancona David, Gallegos Tintoré Santiago, Sandoval Peraza Mukthar, Chel Guerrero Luis
机构信息
Facultad de Ingeniería Química, Universidad Autónoma de Yucatán, Mérida (Yucatán), México..
出版信息
Nutr Hosp. 2015 Nov 1;32(5):2117-25. doi: 10.3305/nh.2015.32.5.9624.
Inhibition of angiotensin-converting enzyme I (ACE-I) in vitro and in vivo from peptide fractions by enzymatic hydrolysis of the Vigna unguiculata protein concentrate was evaluated. Hydrolysis was done with Pepsin-Pancreatin and Flavourzima in two separate systems. The resulting hidrolysates were ultrafiltrated to obtain fractions with different molecular weight. The fractions with better inhibition Flavourzima were size > 1 kDa (> 1 kDa-F) and < 1 kDa (< 1 kDa-F), with an IC50 of 1222.84 and 1098.6 μg/ml respectively. Pepsin-Pancreatin fraction.
评估了通过对豇豆浓缩蛋白进行酶水解从肽级分中体外和体内抑制血管紧张素转换酶I（ACE-I）的情况。在两个独立的系统中分别用胃蛋白酶-胰酶和风味酶进行水解。将所得水解产物进行超滤以获得不同分子量的级分。风味酶水解产物中具有较好抑制作用的级分为分子量>1 kDa（>1 kDa-F）和<1 kDa（<1 kDa-F）的级分，其IC50分别为1222.84和1098.6 μg/ml。胃蛋白酶-胰酶级分。
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