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[家族性良性新生儿惊厥:脑电图、临床、预后及遗传特征]

[Familial benign neonatal seizures: EEG, clinical, prognosis and genetic features].

作者信息

Giroud M, Soichot P, Nivelon-Chevalier A, Gouyon J B, Nivelon J L, Dumas R

机构信息

Service de neurologie, CHU de Dijon, France.

出版信息

Neurophysiol Clin. 1989 Mar;19(1):47-54. doi: 10.1016/s0987-7053(89)80084-x.

Abstract

The authors describe 3 families in which several members presented convulsions exclusively during the neonatal period. The EEG and clinical findings showed typical short neonatal convulsions lasting several months and with no apparent etiology. The dominantly inherited transmission is certain. Prognosis is very good, although 14% of the cases in the literature present an onset of epilepsy after 20 years of age. Even though this phenomenon is unusual, the rarity of its description probably stems from lack of knowledge rather than low incidence. We thus would like to show that, even in the neonatal period, familial epilepsy can occur.

摘要

作者描述了3个家族,其中几名成员仅在新生儿期出现惊厥。脑电图和临床检查结果显示典型的新生儿期短暂惊厥,持续数月,且无明显病因。确定为显性遗传。预后非常好,尽管文献中14%的病例在20岁以后出现癫痫发作。尽管这种现象不常见,其描述的罕见性可能源于认识不足而非发病率低。因此,我们想表明,即使在新生儿期也可能发生家族性癫痫。

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