Service de radiologie, hôpital Brabois, allée du Morvan, 54511 Vandœuvre-lès-Nancy, France.
Service de radiologie, hôpital Brabois, allée du Morvan, 54511 Vandœuvre-lès-Nancy, France.
Diagn Interv Imaging. 2016 Mar;97(3):355-60. doi: 10.1016/j.diii.2015.09.007. Epub 2015 Nov 3.
To describe the multidetector row computed tomography (MDCT) imaging features of HCC that develops in patients who are free from underlying liver cirrhosis and to determine if the MDCT presentation of this specific tumor differs from that of the more common HCC that develops in patients with liver cirrhosis using a retrospective case-control study.
The MDCT examinations of 38 patients with HCC in non-cirrhotic liver (group 1) were quantitatively and qualitatively analyzed and compared to those obtained in 38 patients with HCC in cirrhotic liver (group 2) matched for age and gender. Quantitative and qualitative characteristics of HCC of both groups were compared using univariate analysis.
HCCs were significantly larger in group 1 (81.5mm±55.5) than in group 2 (44.5mm±39.1 SD; P=0.0015). In group 1, HCCs were more frequently single tumors (87%) than in group 2 (37%) (P<0.0001), encapsulated (92% vs. 47% respectively; P<0.0001), had more frequently fatty component (24% vs. 8%, respectively; P=0.0279) and internal hemorrhage (29% vs. 3%, respectively; P=0.0033). No significant differences were found between the two groups for location, hyperenhancement of HCC during the arterial phase, washout during the portal phase, endoluminal portal involvement by HCC, endoportal cruoric thrombus, invasion of adjacent organs and underlying liver steatosis.
HCC in non-cirrhotic liver are larger than those observed in cirrhotic liver and more frequently present as a single encapsulated tumor. They have the same patterns of enhancement than HCC that develops in cirrhotic liver.
描述不伴有肝硬化的肝癌患者多排螺旋 CT（MDCT）的影像学特征，并通过回顾性病例对照研究，确定该特定肿瘤的 MDCT 表现是否与更常见的在肝硬化患者中发生的肝癌不同。
对 38 例不伴肝硬化的肝癌患者（第 1 组）的 MDCT 检查进行定量和定性分析，并与 38 例伴有肝硬化的肝癌患者（第 2 组）的 MDCT 检查进行比较，两组患者在年龄和性别上相匹配。使用单变量分析比较两组 HCC 的定量和定性特征。
第 1 组 HCC 的大小明显大于第 2 组（81.5mm±55.5 比 44.5mm±39.1，P=0.0015）。第 1 组 HCC 多为单发肿瘤（87%比 47%，P<0.0001），包膜完整（92%比 47%，P<0.0001），更常含有脂肪成分（24%比 8%，P=0.0279）和内部出血（29%比 3%，P=0.0033）。两组患者在肿瘤位置、动脉期 HCC 强化、门静脉期廓清、 HCC 累及门静脉内段、门静脉内积血、邻近器官侵犯和基础肝脂肪变性等方面无显著差异。
不伴有肝硬化的肝癌比伴有肝硬化的肝癌体积更大，更常表现为单发包膜完整的肿瘤。它们与在肝硬化中发生的肝癌具有相同的强化模式。
