Bleizgys Andrius, Šapoka Virginijus
Clinic of Internal Diseases, Family Medicine and Oncology of Medical Faculty, Vilnius University, Santariškių 2, LT-08661, Vilnius, Lithuania.
Vilnius University Hospital Santariskiu Clinics, Santariškių 2, LT-08661, Vilnius, Lithuania.
Int J Biometeorol. 2016 Jul;60(7):1075-88. doi: 10.1007/s00484-015-1101-z. Epub 2015 Nov 6.
Vitamin D might have a role in diminishing endothelial dysfunction (ED). The initial aim was to test the hypothesis of reciprocity between levels of 25-hydroxyvitamin D (25(OH)D) and levels of soluble endothelial cell adhesion molecules (CAMs) that could serve as biomarkers of ED. Randomly selected men of age 20-39 were examined at February or March (cold season) and reexamined at August or September (warm season). Some lifestyle and anthropometrical data were recorded. Laboratory measurements, including those for serum levels of soluble CAMs-sICAM-1, sVCAM-1, sE-selectin and sP-selectin-were also performed. As some of the results were rather unexpected, indices of geomagnetic activity (GMA), obtained from the online database, were included in further analysis as a confounder. In 2012-2013, 130 men were examined in cold season, and 125 of them were reexamined in warm season. 25(OH)D levels were found to be significantly negatively associated with sVCAM-1 levels (β = -0.15, p = 0.043 in warm season; β = -0.19, p = 0.007 for changes). Levels of sVCAM-1 and sICAM-1 from the same seasons were notably different between years and have changed in an opposite manner. Soluble P-selectin levels were higher at warm season in both years. GMA was positively associated with sVCAM-1 (β = 0.17, p = 0.039 in cold season; β = 0.22, p = 0.002 for changes) and negatively with sICAM-1 (β = -0.30. p < 0.001 in cold season) levels. Vitamin D might play a role in diminishing sVCAM-1 levels. Levels of sVCAM-1 and sICAM-1 were associated with the GMA; this implies a need for further research.
维生素D可能在减轻内皮功能障碍（ED）方面发挥作用。最初的目的是检验25-羟基维生素D（25(OH)D）水平与可溶性内皮细胞粘附分子（CAMs）水平之间的相互关系假说，后者可作为ED的生物标志物。随机选取年龄在20至39岁之间的男性，于2月或3月（寒冷季节）进行检查，并于8月或9月（温暖季节）再次检查。记录了一些生活方式和人体测量数据。还进行了实验室检测，包括血清可溶性CAMs-sICAM-1、sVCAM-1、sE-选择素和sP-选择素水平的检测。由于部分结果相当出乎意料，从在线数据库获取的地磁活动（GMA）指数作为混杂因素纳入进一步分析。2012 - 2013年，130名男性在寒冷季节接受检查，其中125人在温暖季节再次接受检查。发现25(OH)D水平与sVCAM-1水平显著负相关（温暖季节β = -0.15，p = 0.043；变化时β = -0.19，p = 0.007）。同季节的sVCAM-1和sICAM-1水平在不同年份显著不同，且呈相反变化。两年的温暖季节可溶性P-选择素水平均较高。GMA与sVCAM-1正相关（寒冷季节β = 0.17，p = 0.039；变化时β = 0.22，p = 0.002），与sICAM-1水平负相关（寒冷季节β = -0.30，p < 0.001）。维生素D可能在降低sVCAM-1水平中发挥作用。sVCAM-1和sICAM-1水平与GMA相关；这意味着需要进一步研究。
