Ho Wang Yin G, Sampo M, Soare S, Hoffart L
Service d'ophtalmologie, université d'Aix-Marseille, hôpital de la Timone, 264, rue Saint-Pierre, 13385 Marseille cedex 05, France; Équipe DiMABio, faculté des sciences de Saint-Jérôme, université d'Aix-Marseille, institut Fresnel, avenue Escadrille Normandie-Niemen, 13397 Marseille cedex, France.
Service d'ophtalmologie, université d'Aix-Marseille, hôpital de la Timone, 264, rue Saint-Pierre, 13385 Marseille cedex 05, France.
J Fr Ophtalmol. 2015 Dec;38(10):967-73. doi: 10.1016/j.jfo.2015.07.002. Epub 2015 Nov 5.
To evaluate the effectiveness of a hyperosmolar medication in corneal edema.
This was a prospective randomized study, performed in patients with post-operative corneal edema. Two groups were created: group 1 treated with hypertonic eye drops of 5% sodium chloride with 0.15% sodium hyaluronate in addition to the usual post-operative treatment for 1 month; group 2 without treatment for edema. Visual acuity, pachymetry and corneal density were measured at 1 day, 1 week, 1 month, 3 months and 6 months following surgery.
Forty-four patients were included in group 1 and 42 in group 2. Visual acuity was significantly better in group 1 than in group 2 at 7 days (0.84 logMAR vs 1.55 logMAR, P=0.019 CI 95% [-1.298;-0.128]) and was no longer different at one month, three and six months. Pachymetry decreased significantly in 7 days in group 1 (decrease of 17%, P=0.04, CI 95% [1.987; 258.305]), compared to group 2 (P=0.8, CI 95% [-132.9; 161.8]), but the difference between the 2 groups was not statistically significant (P=0.11, CI 95% [-16; 19.1]). Corneal density was also not significantly different between the two groups.
Five percent sodium chloride hypertonic eye drops show a statistically significant reduction in post-operative corneal edema as shown by the improvement in visual acuity at one week and the downward trend in pachymetry.
评估一种高渗药物治疗角膜水肿的有效性。
这是一项前瞻性随机研究，针对术后角膜水肿患者进行。分为两组：第1组除接受常规术后治疗1个月外，还使用含0.15%透明质酸钠的5%氯化钠高渗滴眼液治疗；第2组未进行水肿治疗。在术后1天、1周、1个月、3个月和6个月测量视力、角膜厚度和角膜密度。
第1组纳入44例患者，第2组纳入42例患者。第1组在7天时的视力明显优于第2组（0.84 logMAR对1.55 logMAR，P = 0.019，95%置信区间[-1.298；-0.128]），1个月、3个月和6个月时两组视力不再有差异。与第2组相比（P = 0.8，95%置信区间[-132.9；161.8]），第1组在7天时角膜厚度显著降低（降低17%，P = 0.04，95%置信区间[1.987；258.305]），但两组之间的差异无统计学意义（P = 0.11，95%置信区间[-16；19.1]）。两组之间的角膜密度也无显著差异。
5%氯化钠高渗滴眼液在术后角膜水肿方面显示出统计学上的显著降低，这体现在1周时视力的改善和角膜厚度的下降趋势上。
