Molecular Structure & Function, The Hospital for Sick Children, 686 Bay Street, Toronto, ON M5G 0A4, Canada.
Molecular Structure & Function, The Hospital for Sick Children, 686 Bay Street, Toronto, ON M5G 0A4, Canada; Department of Biochemistry, University of Toronto, Toronto, ON M5S 1A8, Canada.
Trends Microbiol. 2015 Dec;23(12):746-748. doi: 10.1016/j.tim.2015.10.009. Epub 2015 Nov 5.
Effective treatment of Clostridium difficile infections demands a shift away from antibiotics towards toxin-neutralizing agents. Work by Bender et al., using a drug that attenuates toxin action in vivo without affecting bacterial survival, demonstrates the exciting potential of small molecules as a new modality in the fight against C. difficile.
有效治疗艰难梭菌感染需要从抗生素转向毒素中和剂。Bender 等人的研究使用了一种药物，该药物在不影响细菌存活的情况下减弱毒素的作用，证明了小分子作为一种对抗艰难梭菌的新方法具有令人兴奋的潜力。
