Vidot Denise C, Prado Guillermo, Hlaing WayWay M, Florez Hermes J, Arheart Kristopher L, Messiah Sarah E
Division of Epidemiology and Population Science, Department of Public Health Sciences, University of Miami Leonard M. Miller School of Medicine, Miami, Fla.
Division of Prevention Science and Community Health, Department of Public Health Sciences, University of Miami Leonard M. Miller School of Medicine, Miami, Fla.
Am J Med. 2016 Feb;129(2):173-9. doi: 10.1016/j.amjmed.2015.10.019. Epub 2015 Nov 5.
Research on the health effects of marijuana use in light of its increased medical use and the current obesity epidemic is needed. Our objective was to explore the relationship between marijuana use and metabolic syndrome across stages of adulthood.
An analysis of 20- to 59-year-olds (n = 8478) who completed the 2005-2010 National Health and Nutrition Examination Surveys was conducted. Marijuana use was categorized as: never used, past use (used previously but not within the last 30 days), and current use (≥1 day in the last 30 days). Metabolic syndrome was defined as ≥3 of the following: elevated fasting glucose, high triglycerides, low high-density-lipoprotein cholesterol, elevated systolic/diastolic blood pressure, and increased waist circumference. An age-stratified analysis was conducted to examine the relationship between marijuana use and metabolic syndrome among emerging adults (20-30 years), adults (31-44 years), and middle-aged adults (45-59 years).
Fourteen percent (13.8%) of current marijuana users and 17.5% of past marijuana users presented with metabolic syndrome, compared with 19.5% of never users (P = .0003 and P = .03, respectively). Current marijuana users had lower odds of presenting with metabolic syndrome than never users (adjusted odds ratio [AOR] 0.69; 95% confidence interval [CI], 0.47-1.00; P = .05). Among emerging adults, current marijuana users were 54% less likely than never users to present with metabolic syndrome. Current (AOR 0.49; 95% CI, 0.25-0.97) and past (AOR 0.61; 95% CI, 0.40-0.91) middle-aged adult marijuana users were less likely to have metabolic syndrome than never users.
Current marijuana use is associated with lower odds of metabolic syndrome across emerging and middle-aged US adults. Future studies should examine the biological pathways of this relationship.
鉴于大麻医疗用途的增加以及当前的肥胖流行趋势，有必要对大麻使用对健康的影响进行研究。我们的目标是探讨成年各阶段大麻使用与代谢综合征之间的关系。
对完成2005 - 2010年国家健康和营养检查调查的20至59岁人群（n = 8478）进行分析。大麻使用情况分为：从未使用、过去使用（以前使用过但过去30天内未使用）和当前使用（过去30天内使用≥1天）。代谢综合征定义为以下情况中的≥3种：空腹血糖升高、甘油三酯升高、高密度脂蛋白胆固醇降低、收缩压/舒张压升高以及腰围增加。进行了年龄分层分析，以研究新兴成年人（20 - 30岁）、成年人（31 - 44岁）和中年成年人（45 - 59岁）中大麻使用与代谢综合征之间的关系。
当前大麻使用者中有14%（13.8%）、过去大麻使用者中有17.5%患有代谢综合征，而从未使用者中有19.5%患有代谢综合征（P分别为0.0003和0.03）。当前大麻使用者患代谢综合征的几率低于从未使用者（调整后的优势比[AOR]为0.69；95%置信区间[CI]，0.47 - 1.00；P = 0.05）。在新兴成年人中，当前大麻使用者患代谢综合征的可能性比从未使用者低54%。当前（AOR 0.49；95% CI，0.25 - 0.97）和过去（AOR 0.61；95% CI，0.40 - 0.91）的中年大麻使用者患代谢综合征的可能性低于从未使用者。
在美国新兴和中年成年人中，当前使用大麻与患代谢综合征的几率较低有关。未来的研究应探讨这种关系的生物学途径。
