Ponto Laura L Boles, Brashers-Krug Thomas M, Pierson Ronald K, Menda Yusuf, Acion Laura, Watkins G Leonard, Sunderland John J, Koeppel Julie A, Jorge Ricardo E
From the Depts. of Radiology (LLBP, YM, GLW, JJS) and Psychiatry (TMB-K, JAK), Roy J. and Lucille A. Carver College of Medicine, and the Dept. of Biostatistics, College of Public Health (LA), University of Iowa, Iowa City, IA; the Iowa City Veterans Administration Medical Center (TMB-K), Iowa City, IA; Brain Image Analysis, LLC, Iowa City, IA (RKP); the Iowa Consortium for Substance Abuse Research and Evaluation, Iowa City, IA (LA); and the Michael E. DeBakey Veterans Affairs Medical Center, Houston, TX (REJ).
J Neuropsychiatry Clin Neurosci. 2016 Spring;28(2):89-96. doi: 10.1176/appi.neuropsych.15050106. Epub 2015 Nov 9.
This study aimed to examine global and regional cerebral blood flow and amyloid burden in combat veterans with and without traumatic brain injury (TBI). Cerebral blood flow (in milliliters per minute per 100 mL) was measured by quantitative [(15)O]water, and amyloid burden was measured by [(11)C]PIB imaging. Mean global cerebral blood flow was significantly lower in veterans with TBI compared with non-TBI veterans. There were essentially no differences between groups for globally normalized regional cerebral blood flow. Amyloid burden did not differ between TBI and non-TBI veterans. Veterans who have suffered a TBI have significantly lower cerebral blood flow than non-TBI controls but did not manifest increased levels of amyloid, globally or regionally.
本研究旨在检查有和没有创伤性脑损伤（TBI）的退伍军人的全脑和局部脑血流量以及淀粉样蛋白负荷。脑血流量（每分钟每100 mL的毫升数）通过定量[（15）O]水测量，淀粉样蛋白负荷通过[（11）C]PIB成像测量。与无TBI的退伍军人相比，有TBI的退伍军人的平均全脑血流量显著更低。两组之间在全脑标准化局部脑血流量方面基本没有差异。TBI退伍军人和非TBI退伍军人之间的淀粉样蛋白负荷没有差异。遭受TBI的退伍军人的脑血流量明显低于非TBI对照，但在全脑或局部均未表现出淀粉样蛋白水平升高。
