Kaleita T A, Shields W D, Tesler A, Feig S A
Department of Pediatrics, UCLA School of Medicine 90024.
Pediatrics. 1989 May;83(5):753-7.
Longitudinal neurodevelopmental studies of four consecutive young children treated by bone marrow transplantation for acute leukemia or aplastic anemia are presented. The children, the only four children less than 2 years of age who have received bone marrow transplants for these diseases at UCLA Medical Center, ranged in age from 36 weeks to 24 months at the time of transplantation. Conditioning involved high-dose cyclophosphamide treatment; three also had total body irradiation prior to bone marrow transplantation. Their respective outcomes after follow-up times of 28 months to 71 months posttransplantation are remarkable for normal somatic growth and normal development of intelligence, language, perception, and motor coordination. These findings indicate that future therapeutic studies of infants and young children with acute leukemia or aplastic anemia using total body irradiation, cyclophosphamide, and bone marrow transplantation are not contraindicated by risks of debilitating neurodevelopmental sequelae.
本文介绍了对四名连续接受骨髓移植治疗急性白血病或再生障碍性贫血的幼儿进行的纵向神经发育研究。这些儿童是加州大学洛杉矶分校医学中心仅有的四名年龄小于2岁且因这些疾病接受骨髓移植的儿童，移植时年龄在36周至24个月之间。预处理包括高剂量环磷酰胺治疗；其中三人在骨髓移植前还接受了全身照射。在移植后28个月至71个月的随访期后，他们各自的结果显示出正常的身体生长以及智力、语言、感知和运动协调能力的正常发育。这些发现表明，对于患有急性白血病或再生障碍性贫血的婴幼儿，未来使用全身照射、环磷酰胺和骨髓移植的治疗研究不会因导致神经发育后遗症的风险而受到禁忌。
