出版物《环己烷-1,2-二羧酸二异壬酯及其代谢物对大鼠附睾基质血管部分脂肪组织分化的影响》，作者 Enrico Campioli、Tam B. Duong、François Deschamps、Vassilios Papadopoulos，发表于《环境研究》140（2015 年），第 145-156 页，值得一些批判性的评论。
The publication "Cyclohexane-1,2-dicarboxylic acid diisononyl ester and metabolite effects on rat epididymal stromal vascular fraction differentiation of adipose tissue" by Enrico Campioli, Tam B. Duong, François Deschamps, Vassilios Papadopoulos, Environmental Research 140 (2015), 145-156, merits some critical comments.
机构信息
BASF SE, E-CPI/R, Carl-Bosch-Str. 38, 67056 Ludwigshafen, Germany.
出版信息
Environ Res. 2016 Jan;144(Pt A):165-166. doi: 10.1016/j.envres.2015.08.021. Epub 2015 Nov 6.
PMID:26548739
Abstract
In essence, the authors report MINCH, a monoester and minor urinary metabolite (Koch et al., 2013) of a plasticizer marketed by BASF under the brandname Hexamoll(®) DINCH(®), promotes the differentiation of preadipocytes derived from rat epididymal stromal vascular fraction (SVF) to adipocytes. The authors have over-interpreted their in-vitro data and missed important publicly available in-vivo data.
摘要
本质上，作者报告了 MINCH，一种增塑剂的单酯和次要尿代谢物（Koch 等人，2013 年），由 BASF 以商标名 Hexamoll（®）DINCH（®）销售，促进了大鼠附睾基质血管部分（SVF）来源的前体脂肪细胞向脂肪细胞的分化。作者对他们的体外数据进行了过度解释，忽略了重要的可公开获取的体内数据。
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