Deramoudt-Dutrus V, Betremieux P, Lefrançois C, Malledant Y, Avril J L, Le Marec B
Département d'anesthésie-réanimation, CHR, Rennes, France.
Pediatrie. 1989;44(2):125-32.
A study was carried out to determine amikacin blood levels in 44 neonates who were admitted to a Pediatric Intensive Care Unit. Amikacin was administered by intravenous or intramuscular route. The levels obtained with both methods were similar. The results of our study indicate that amikacin levels should be monitored in neonates to avoid toxic concentrations of this drug. On the basis of this study a new neonatal dosage schedule is proposed.
一项研究旨在测定44名入住儿科重症监护病房的新生儿的阿米卡星血药浓度。阿米卡星通过静脉或肌肉注射途径给药。两种给药方法所测得的血药浓度相似。我们的研究结果表明，应对新生儿的阿米卡星血药浓度进行监测，以避免该药物出现毒性浓度。基于这项研究，提出了一种新的新生儿用药剂量方案。
