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[儿童肾移植中的三联免疫抑制:3年经验]

[Triple immunosuppression in renal transplantation in children: 3 years' experience].

作者信息

Trompeter R S

机构信息

Department of Paediatric Nephrology, Royal Free Hospital, London, England.

出版信息

Pediatrie. 1989;44(2):87-91.

PMID:2654877
Abstract

Cyclosporin A in combination with low-dose steroid therapy and azathioprine was given to 50 children who received 53 renal transplants. In spite of a limited period of observation, the use of cyclosporin A, either on a post operative intravenous regime or on oral regime when primary graft function is achieved, has no significant influence on graft survival rate, which is 82% after 1 and 2 years, utilising cadaver donors. Vascular complications were responsible for the loss of 4 grafts and were associated with the use of kidneys from young donors, rather than the type of immunosuppressive agents used.

摘要

50名接受了53次肾移植的儿童接受了环孢素A联合小剂量类固醇疗法和硫唑嘌呤的治疗。尽管观察期有限,但无论是术后静脉给药方案还是在移植肾功能恢复后采用口服给药方案,使用环孢素A对移植肾存活率均无显著影响。使用尸体供肾时,1年和2年后的移植肾存活率为82%。4次移植肾失功是由血管并发症导致的,且这些并发症与使用年轻供者的肾脏有关,而非所用免疫抑制剂的类型。

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