过氧化物酶体增殖物激活受体γ（PPARG）rs1801282 C>G多态性与亚洲人癌症易感性相关：一项更新的荟萃分析。
Peroxisome proliferator-activated receptor gamma (PPARG) rs1801282 C>G polymorphism is associated with cancer susceptibility in asians: an updated meta-analysis.
作者信息
Wang Yafeng, Chen Yu, Jiang Heping, Tang Weifeng, Kang Mingqiang, Liu Tianyun, Guo Zengqing, Ma Zhiqiang
机构信息
Department of Cardiology, The People's Hospital of Xishuangbanna Dai Autonomous Prefecture Jinghong, Yunnan Province, China.
Department of Medical Oncology, Fujian Provincial Cancer Hospital Fuzhou, Fujian Province, China.
出版信息
Int J Clin Exp Med. 2015 Aug 15;8(8):12661-73. eCollection 2015.
Peroxisome proliferator-activated receptor gamma (PPARG) is related to inflammation and plays an important role in the development of cancer. PPARG rs1801282 C>G polymorphism might influence the risk of cancer by regulating production of PPARG gene. Hence, a comprehensive meta-analysis was conducted to explore the association of PPARG rs1801282 C>G polymorphism with cancer susceptibility. An extensive search of PubMed and Embase databases for all relevant publications was carried out. A total of 38 publications with 16,844 cancer cases and 23,736 controls for PPARG rs1801282 C>G polymorphism were recruited in our study. Our results indicated that PPARG rs1801282 C>G variants were associated with an increased cancer risk in Asian populations and gastric cancer. In summary, the findings suggest that PPARG rs1801282 C>G polymorphism may play a crucial role in malignant transformation and the development of cancer.
过氧化物酶体增殖物激活受体γ（PPARG）与炎症相关，在癌症发展过程中发挥重要作用。PPARG rs1801282 C>G多态性可能通过调节PPARG基因的产生来影响癌症风险。因此，进行了一项全面的荟萃分析，以探讨PPARG rs1801282 C>G多态性与癌症易感性之间的关联。对PubMed和Embase数据库进行了广泛检索，以查找所有相关出版物。我们的研究共纳入了38篇关于PPARG rs1801282 C>G多态性的出版物，涉及16,844例癌症病例和23,736例对照。我们的结果表明，PPARG rs1801282 C>G变异与亚洲人群和胃癌的癌症风险增加相关。总之，研究结果表明PPARG rs1801282 C>G多态性可能在恶性转化和癌症发展中起关键作用。
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