Ding Hao, Chen Yuanmei, Qiu Hao, Liu Chao, Wang Yafeng, Kang Mingqiang, Tang Weifeng
Department of Respiratory Disease, Affiliated People's Hospital of Jiangsu University, Zhenjiang, Jiangsu Province, China.
Department of Thoracic Surgery, Fujian Cancer Hospital, Fujian Medical University Cancer Hospital, Fuzhou, Fujian Province, China.
Oncotarget. 2017 Sep 15;8(60):102277-102290. doi: 10.18632/oncotarget.20925. eCollection 2017 Nov 24.
Recently, several studies suggested that polymorphism was correlated with cancer risk. However, past results remained controversial. In this study, we performed a case-control study on the relationship of polymorphism with risk of non-small cell lung cancer (NSCLC) and subsequently carried out a meta-analysis to further assess the association between and overall cancer. In our case-control study, after adjusting by age, sex, body mass index (BMI), smoking and drinking, a tendency to increased NSCLC risk was noted (CT/TT vs. CC: adjusted OR, 1.21; 95% CI, 0.97-1.51; = 0.097). In the meta-analysis, we found a significant association between polymorphism and overall cancer risk (T vs. C: OR, 1.13; 95% CI, 1.03-1.23; = 0.006; TT vs. CC: OR, 1.29; 95% CI, 1.07-1.56; = 0.008, CT/TT vs. CC: OR, 1.11; 95% CI, 1.02-1.21; = 0.014 and TT vs.
CT/CC: OR, 1.26; 95% CI, 1.04-1.52; = 0.016). In a subgroup analysis by ethnicity, evidence of significant association between polymorphism and cancer risk was found among Asians and mixed populations. In a subgroup analysis by cancer type, polymorphism was associated with risk of esophageal cancer and glioblastoma. In addition, in a subgroup analysis by origin of cancer cell, evidence of significant association between polymorphism and cancer risk was also found among epithelial tumor. In conclusion, the findings indicate polymorphism may increase the susceptibility of cancer.
最近，多项研究表明多态性与癌症风险相关。然而，过去的结果仍存在争议。在本研究中，我们针对多态性与非小细胞肺癌（NSCLC）风险的关系进行了一项病例对照研究，随后进行了一项荟萃分析，以进一步评估[多态性]与总体癌症之间的关联。在我们的病例对照研究中，在对年龄、性别、体重指数（BMI）、吸烟和饮酒进行调整后，发现NSCLC风险有增加的趋势（CT/TT与CC相比：调整后的OR为1.21；95%CI为0.97 - 1.51；P = 0.097）。在荟萃分析中，我们发现[多态性]与总体癌症风险之间存在显著关联（T与C相比：OR为1.13；95%CI为1.03 - 1.23；P = 0.006；TT与CC相比：OR为1.29；95%CI为1.07 - 1.56；P = 0.008，CT/TT与CC相比：OR为1.11；95%CI为1.02 - 1.21；P = 0.014以及TT与CT/CC相比：OR为1.26；95%CI为1.04 - 1.52；P = 0.016）。在按种族进行的亚组分析中，在亚洲人和混合人群中发现了[多态性]与癌症风险之间存在显著关联的证据。在按癌症类型进行的亚组分析中，[多态性]与食管癌和胶质母细胞瘤的风险相关。此外，在按癌细胞起源进行的亚组分析中，在上皮肿瘤中也发现了[多态性]与癌症风险之间存在显著关联的证据。总之，研究结果表明[多态性]可能会增加患癌易感性。
