职业性吸入质子泵抑制剂所致接触性皮炎。

Occupational Airborne Contact Dermatitis From Proton Pump Inhibitors.

机构信息

From the *Division of Dermatology, University of Toronto; and †Department of Occupational and Environmental Health, St. Michael's Hospital, Toronto; and ‡University of Ottawa, Ontario, Canada.

出版信息

Dermatitis. 2015 Nov-Dec;26(6):287-90. doi: 10.1097/DER.0000000000000139.

DOI:10.1097/DER.0000000000000139

PMID:26551609

Abstract

Few published reports have described occupational contact dermatitis from proton pump inhibitor (PPI) exposure in the literature. We present an additional case of a 58-year-old male pharmaceutical worker with an occupational airborne allergic contact dermatitis to PPIs confirmed by patch testing. This is a novel report of workplace exposure to dexlansoprazole and esomeprazole PPIs with resultant clinical contact allergy and relevant positive patch test results to these 2 agents. A literature review of all previously reported cases of occupational contact dermatitis to PPI is summarized. The case also emphasizes the importance of even minute exposures when considering workplace accommodation.

摘要

文献中鲜有质子泵抑制剂（PPI）暴露引起职业性接触性皮炎的报道。我们报告了另 1 例职业性吸入性变应性接触性皮炎的病例，该病例为 58 岁男性制药工人，经斑贴试验证实对 PPIs 过敏。这是首例关于工作场所接触地兰索拉唑和埃索美拉唑 PPIs 导致临床接触过敏以及这两种药物斑贴试验阳性的报告。对所有先前报道的职业性接触性皮炎病例进行了文献复习。该病例还强调了在考虑工作场所适应时，即使是微小暴露也很重要。