在小鼠中使用人源化剂量通过药代动力学/药效学研究评估米卡芬净延长给药间隔的疗效。
Efficacy of Extended-Interval Dosing of Micafungin Evaluated Using a Pharmacokinetic/Pharmacodynamic Study with Humanized Doses in Mice.
作者信息
Lepak A, Marchillo K, VanHecker J, Azie N, Andes D
机构信息
University of Wisconsin, Madison, Wisconsin, USA.
Middleton VA Hospital, Madison, Wisconsin, USA.
出版信息
Antimicrob Agents Chemother. 2015 Nov 9;60(1):674-7. doi: 10.1128/AAC.02124-15. Print 2016 Jan.
Abstract
The pharmacokinetic/pharmacodynamic (PK/PD) characteristics of the echinocandins favor infrequent administration of large doses. The in vivo investigation reported here tested the utility of a range of humanized dose levels of micafungin using a variety of prolonged dosing intervals for the prevention and therapy of established disseminated candidiasis. Humanized doses of 600 mg administered every 6 days prevented fungal growth in prophylaxis. Humanized doses of 300 to 1,000 mg administered every 6 days demonstrated efficacy for established infections.
摘要
棘白菌素类药物的药代动力学/药效学（PK/PD）特性有利于大剂量的不频繁给药。本文报道的体内研究使用多种延长的给药间隔，测试了一系列人源化剂量的米卡芬净对已确诊的播散性念珠菌病的预防和治疗效果。每6天给予600mg的人源化剂量可预防真菌感染。每6天给予300至1000mg的人源化剂量对已确诊的感染显示出疗效。
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