Howard Alex, Hope William
Antimicrobial Pharmacodynamics and Therapeutics, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool L7 8TX, Merseyside, UK.
J Fungi (Basel). 2023 Feb 1;9(2):192. doi: 10.3390/jof9020192.
Pharmacokinetic-pharmacodynamic (PK-PD) analysis is of central importance to the progress of an antifungal agent into clinical use. It is crucial to ensure that preclinical studies give the best possible prediction of the way drugs are likely to behave in a clinical setting. This review details the last 30 years of progress in terms of disease model design, efficacy outcome selection and translational modelling in antifungal PK-PD studies. The principles of how PK-PD parameters inform current clinical practice are also discussed, including a review of how these apply to existing and novel agents.
药代动力学-药效学（PK-PD）分析对于抗真菌药物进入临床应用的进展至关重要。确保临床前研究能够尽可能准确地预测药物在临床环境中的行为方式至关重要。本综述详细介绍了抗真菌PK-PD研究在疾病模型设计、疗效结果选择和转化建模方面过去30年的进展。还讨论了PK-PD参数如何为当前临床实践提供依据的原则，包括对这些参数如何应用于现有和新型药物的综述。
