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柯氏音的起源及听诊法测量血压的准确性。

The origin of Korotkoff sounds and the accuracy of auscultatory blood pressure measurements.

作者信息

Babbs Charles F

机构信息

Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, USA.

出版信息

J Am Soc Hypertens. 2015 Dec;9(12):935-50.e3. doi: 10.1016/j.jash.2015.09.011. Epub 2015 Sep 25.

Abstract

This study explores the hypothesis that the sharper, high frequency Korotkoff sounds come from resonant motion of the arterial wall, which begins after the artery transitions from a buckled state to an expanding state. The motions of one mass, two nonlinear springs, and one damper, driven by transmural pressure under the cuff, are used to model and compute the Korotkoff sounds according to principles of classical Newtonian physics. The natural resonance of this spring-mass-damper system provides a concise, yet rigorous, explanation for the origin of Korotkoff sounds. Fundamentally, wall stretching in expansion requires more force than wall bending in buckling. At cuff pressures between systolic and diastolic arterial pressure, audible vibrations (> 40 Hz) occur during early expansion of the artery wall beyond its zero pressure radius after the outward moving mass of tissue experiences sudden deceleration, caused by the discontinuity in stiffness between bucked and expanded states. The idealized spring-mass-damper model faithfully reproduces the time-domain waveforms of actual Korotkoff sounds in humans. Appearance of arterial sounds occurs at or just above the level of systolic pressure. Disappearance of arterial sounds occurs at or just above the level of diastolic pressure. Muffling of the sounds is explained by increased resistance of the artery to collapse, caused by downstream venous engorgement. A simple analytical model can define the physical origin of Korotkoff sounds, suggesting improved mechanical or electronic filters for their selective detection and confirming the disappearance of the Korotkoff sounds as the optimal diastolic end point.

摘要

本研究探讨了以下假设

更尖锐的高频柯氏音源于动脉壁的共振运动,这种运动在动脉从屈曲状态转变为扩张状态后开始。根据经典牛顿物理学原理,使用由袖带下方的跨壁压力驱动的一个质量块、两个非线性弹簧和一个阻尼器的运动来模拟和计算柯氏音。这种弹簧 - 质量 - 阻尼系统的自然共振为柯氏音的起源提供了一个简洁而严谨的解释。从根本上说,扩张时的壁拉伸比屈曲时的壁弯曲需要更多的力。在袖带压力处于收缩压和舒张压之间时,在组织向外移动的质量块突然减速后,动脉壁在超出其零压力半径的早期扩张过程中会出现可听振动(>40Hz),这是由屈曲和扩张状态之间的刚度不连续性引起的。理想化的弹簧 - 质量 - 阻尼模型忠实地再现了人类实际柯氏音的时域波形。动脉音出现在收缩压水平或略高于收缩压水平。动脉音消失在舒张压水平或略高于舒张压水平。声音的减弱是由于下游静脉充血导致动脉抗塌陷阻力增加所致。一个简单的分析模型可以定义柯氏音的物理起源,这表明可以改进机械或电子滤波器用于其选择性检测,并确认柯氏音的消失作为最佳舒张压终点。

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