Pérez-Silva José G, Español Yaiza, Velasco Gloria, Quesada Víctor
From the Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, Instituto Universitario de Oncología, Universidad de Oviedo, 33006 Oviedo, Spain.
From the Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, Instituto Universitario de Oncología, Universidad de Oviedo, 33006 Oviedo, Spain
Nucleic Acids Res. 2016 Jan 4;44(D1):D351-5. doi: 10.1093/nar/gkv1201. Epub 2015 Nov 8.
Since the definition of the degradome as the complete repertoire of proteases in a given organism, the combined effort of numerous laboratories has greatly expanded our knowledge of its roles in biology and pathology. Once the genomic sequences of several important model organisms were made available, we presented the Degradome database containing the curated sets of known protease genes in human, chimpanzee, mouse and rat. Here, we describe the updated Degradome database, featuring 81 new protease genes and 7 new protease families. Notably, in this short time span, the number of known hereditary diseases caused by mutations in protease genes has increased from 77 to 119. This increase reflects the growing interest on the roles of the degradome in multiple diseases, including cancer and ageing. Finally, we have leveraged the widespread adoption of new webtools to provide interactive graphic views that show information about proteases in the global context of the degradome. The Degradome database can be accessed through its web interface at http://degradome.uniovi.es.
自从将降解组定义为特定生物体中蛋白酶的完整集合以来，众多实验室的共同努力极大地扩展了我们对其在生物学和病理学中作用的认识。一旦几种重要模式生物的基因组序列可用，我们就推出了降解组数据库，其中包含人类、黑猩猩、小鼠和大鼠中已知蛋白酶基因的精选集。在此，我们描述了更新后的降解组数据库，其特点是有81个新的蛋白酶基因和7个新的蛋白酶家族。值得注意的是，在这么短的时间内，由蛋白酶基因突变引起的已知遗传性疾病数量已从77种增加到119种。这一增长反映了人们对降解组在包括癌症和衰老在内的多种疾病中作用的兴趣日益浓厚。最后，我们利用了新网络工具的广泛应用，提供交互式图形视图，展示在降解组的整体背景下有关蛋白酶的信息。可通过其网页界面http://degradome.uniovi.es访问降解组数据库。
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