伴有情绪障碍的快速脂肪沉积。
Rapid adipose deposition with mood disorders.
作者信息
Fiedorowicz Jess G, Andersen Lorick E, Persons Jane E, Calarge Chadi
机构信息
Department of Psychiatry, Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine, Iowa City, IA USA, Department of Epidemiology, College of Public Health, University of Iowa, Iowa City, IA USA. E-mail:
出版信息
Ann Clin Psychiatry. 2015 Nov;27(4):283-8.
BACKGROUND
Persons with bipolar disorder represent a high-risk group for obesity, but little is known about the time course by which weight gain occurs in bipolar disorder.
METHODS
We prospectively studied changes in fat distribution using dual-energy x-ray absorptiometry in relationship to medication exposure and mood symptom burden in 36 participants with bipolar disorder. We assessed the relationship between prior medication exposure and course of illness with adiposity measures at baseline (N = 36) and at 6-month follow-up (N = 22).
RESULTS
At baseline, greater adiposity was associated with advanced age and female sex, not retrospectively assessed symptom course or medication exposure (past 2 years). Over 6 months of prospective follow-up, participants developed greater adiposity (fat mass index +0.82 kg/m(²), P = .007; visceral fat area +8.6 cm(²), P = .02; total percent fat +1.6%, P = .02). Manic symptomatology, not antipsychotic exposure, was related to the increased adiposity.
CONCLUSIONS
Acute exacerbations of mood disorders appear to represent high-risk periods for adipose deposition. Obesity prevention efforts may be necessary during acute exacerbations.
背景
双相情感障碍患者是肥胖的高危人群，但对于双相情感障碍患者体重增加的时间进程了解甚少。
方法
我们前瞻性地研究了36名双相情感障碍患者使用双能X线吸收法测量的脂肪分布变化与药物暴露及情绪症状负担之间的关系。我们在基线时（N = 36）和6个月随访时（N = 22）评估了既往药物暴露和疾病进程与肥胖测量指标之间的关系。
结果
在基线时，更高的肥胖程度与高龄和女性性别相关，而非回顾性评估的症状进程或药物暴露（过去2年）。在6个月的前瞻性随访中，参与者的肥胖程度增加（脂肪量指数增加0.82 kg/m²，P = 0.007；内脏脂肪面积增加8.6 cm²，P = 0.02；总脂肪百分比增加1.6%，P = 0.02）。躁狂症状而非抗精神病药物暴露与肥胖程度增加有关。
结论
情绪障碍的急性加重期似乎是脂肪沉积的高危时期。在急性加重期可能需要进行肥胖预防工作。
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