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光学相干断层扫描及对比敏感度测试在观察妊娠高血压综合征患者眼底变化中的应用

Application of Optical Coherence Tomography and Contrast Sensitivity Test for Observing Fundus Changes of Patients With Pregnancy-Induced Hypertension Syndrome.

作者信息

Wang Zhixue, Zou Yuanyuan, Li Wenying, Wang Xueyan, Zhang Min, Wang Wenying

机构信息

From the Department of Ophthalmology, Cangzhou Central Hospital, Cangzhou, Hebei, China.

出版信息

Medicine (Baltimore). 2015 Nov;94(44):e1641. doi: 10.1097/MD.0000000000001641.

Abstract

This study was aimed to investigate the fundus changes of patients with pregnancy-induced hypertension syndrome (PIHS) using optical coherence tomography (OCT) technology and contrast sensitivity (CS) tests.Ninety-eight patients with PIHS underwent routine eye examinations including vision correction, fundus examination, OCT, and CS tests. The CS test was performed at low, medium, and high frequency, respectively. Moreover, the difference in CS tests between 2 groups was analyzed by independent-samples T test. The Kruskal-Wallis rank sum test and linear regression model were used to detect the correlation of OCT with CS, respectively. Meanwhile Satterthwaite approximate T test was adopted for pairwise comparisons after nonparametric analysis of variance.The OCT test revealed that 56.76% of the examined eyes showed shallow retinal detachment in the macula lutea and around the optic disk. The differences in CS at each spatial frequency between the case and control group were statistically significant (P < 0.01). Besides, OCT manifestations were associated with CS at each spacial frequency including 1.5, 3, 6, 12, and 18 frequency (P < 0.01). And patients with abnormal manifestations of OCT showed lower CS at each spacial frequency than those without abnormal OCT manifestations. What's more the OCT manifestation 1 showed the greatest impact on CS at each spacial frequency.The results showed that abnormal OCT manifestations were correlated with CS in PIHS. OCT and CS tests might be valuable methods in observing fundus changes for PIHS patients.

摘要

本研究旨在利用光学相干断层扫描(OCT)技术和对比敏感度(CS)测试来调查妊娠高血压综合征(PIHS)患者的眼底变化。98例PIHS患者接受了包括视力矫正、眼底检查、OCT和CS测试在内的常规眼部检查。CS测试分别在低频、中频和高频下进行。此外,通过独立样本t检验分析两组之间CS测试的差异。分别使用Kruskal-Wallis秩和检验和线性回归模型来检测OCT与CS的相关性。同时,在非参数方差分析后采用Satterthwaite近似t检验进行两两比较。OCT测试显示,56.76%的受检眼在黄斑和视盘周围出现浅视网膜脱离。病例组和对照组在每个空间频率下的CS差异具有统计学意义(P<0.01)。此外,OCT表现与每个空间频率(包括1.5、3、6、12和18频率)下的CS相关(P<0.01)。OCT表现异常的患者在每个空间频率下的CS均低于OCT表现正常的患者。而且OCT表现1对每个空间频率下的CS影响最大。结果表明,PIHS患者中OCT异常表现与CS相关。OCT和CS测试可能是观察PIHS患者眼底变化的有价值方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c532/4915865/89fcb3ec8426/medi-94-e1641-g001.jpg

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