Alcorcon Foundation University Hospital Ophthalmology Unit, Madrid, Spain.
Ophthalmic Physiol Opt. 2013 Mar;33(2):164-71. doi: 10.1111/opo.12017. Epub 2013 Jan 12.
To compare optic disc area measurement between optic nerve head drusen (ONHD) and control subjects using fundus photography, time-domain optical coherence tomography (TD-OCT) and spectral-domain optical coherence tomography (SD-OCT). We also made a comparison between each of the three techniques.
We performed our study on 66 eyes (66 patients) with ONHD and 70 healthy control subjects (70 controls) with colour ocular fundus photography at 20º (Zeiss FF 450 IR plus), TD-OCT (Stratus OCT) with the Fast Optic Disc protocol and SD-OCT (Cirrus OCT) with the Optic Disc Cube 200 × 200 protocol for measurement of the optic disc area. The measurements were made by two observers and in each measurement a correction of the image magnification factor was performed. Measurement comparison using the Student's t-test/Mann-Whitney U test, the intraclass correlation coefficient, Pearson/Spearman rank correlation coefficient and the Bland-Altman plot was performed in the statistical analysis.
Mean and standard deviation (SD) of the optic disc area in ONHD and in controls was 2.38 (0.54) mm(2) and 2.54 (0.42) mm(2), respectively with fundus photography; 2.01 (0.56) mm(2) and 1.66 (0.37) mm(2), respectively with TD-OCT, and 2.03 (0.49) mm(2) and 1.75 (0.38) mm(2), respectively with SD-OCT. In ONHD and controls, repeatability of optic disc area measurement was excellent with fundus photography and optical coherence tomography (TD-OCT and SD-OCT), but with a low degree of agreement between both techniques.
Optic disc area measurement is smaller in ONHD compared to healthy subjects with fundus photography, unlike time-domain and spectral-domain optical coherence tomography in which the reverse is true. Both techniques offer good repeatability, but a low degree of correlation and agreement, which means that optic disc area measurement is not interchangeable or comparable between techniques.
使用眼底照相、时域光相干断层扫描（TD-OCT）和频域光相干断层扫描（SD-OCT）比较视神经乳头玻璃膜疣（ONHD）和对照组的视盘面积测量值。我们还比较了这三种技术的每一种。
我们对 66 只眼（66 例患者）的 ONHD 和 70 只健康对照组（70 例对照）进行了研究，使用 20°彩色眼部眼底照相（Zeiss FF 450 IR plus）、TD-OCT（Stratus OCT）的快速视盘协议和 SD-OCT（Cirrus OCT）的视盘立方 200×200 协议测量视盘面积。由两名观察者进行测量，并在每次测量中都进行了图像放大倍率的校正。在统计分析中，使用学生 t 检验/曼-惠特尼 U 检验、组内相关系数、皮尔逊/斯皮尔曼秩相关系数和 Bland-Altman 图进行测量比较。
ONHD 和对照组的视盘面积平均值和标准差（SD）分别为眼底照相 2.38（0.54）mm²和 2.54（0.42）mm²；TD-OCT 分别为 2.01（0.56）mm²和 1.66（0.37）mm²；SD-OCT 分别为 2.03（0.49）mm²和 1.75（0.38）mm²。在 ONHD 和对照组中，眼底照相和光学相干断层扫描（TD-OCT 和 SD-OCT）对视盘面积测量的重复性均良好，但两种技术之间的一致性程度较低。
与健康对照组相比，眼底照相对视盘面积的测量值在 ONHD 中较小，而与时域和频域光学相干断层扫描相反。两种技术的重复性均良好，但相关性和一致性程度较低，这意味着不同技术对视盘面积的测量值不能互换或比较。
