胰岛淀粉样多肽抑制分离的大鼠胰岛的葡萄糖刺激的胰岛素分泌。
Islet amyloid polypeptide inhibits glucose-stimulated insulin secretion from isolated rat pancreatic islets.
作者信息
Ohsawa H, Kanatsuka A, Yamaguchi T, Makino H, Yoshida S
机构信息
Second Department of Internal Medicine, Chiba University, School of Medicine, Japan.
出版信息
Biochem Biophys Res Commun. 1989 Apr 28;160(2):961-7. doi: 10.1016/0006-291x(89)92529-1.
Islet amyloid polypeptide has 37 amino acids and is a major component of amyloid deposition in pancreatic islets of patients with type 2 diabetes mellitus. To determine whether the peptide is involved in the impaired insulin secretion in this type of diabetes mellitus, we synthesized islet amyloid polypeptide and its fragments and examined its effect on insulin secretion. Islet amyloid polypeptide inhibited the glucose-stimulated insulin secretion from isolated rat pancreatic islets, as calcitonin gene-related peptide did, but the fragments failed to inhibit the secretion. Thus, we propose that amyloid deposition may be an important factor in the impairment of insulin secretion in type 2 diabetes mellitus.
胰岛淀粉样多肽由37个氨基酸组成，是2型糖尿病患者胰岛中淀粉样沉积物的主要成分。为了确定该肽是否参与了此类糖尿病中胰岛素分泌受损的过程，我们合成了胰岛淀粉样多肽及其片段，并检测了其对胰岛素分泌的影响。胰岛淀粉样多肽如同降钙素基因相关肽一样，抑制了分离的大鼠胰岛对葡萄糖刺激的胰岛素分泌，但这些片段未能抑制该分泌。因此，我们提出淀粉样沉积可能是2型糖尿病中胰岛素分泌受损的一个重要因素。
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