酰胺化大鼠胰岛淀粉样多肽对大鼠体内和体外葡萄糖刺激的胰岛素分泌的影响。
Effects of amidated rat islet amyloid polypeptide on glucose-stimulated insulin secretion in vivo and in vitro in rats.
作者信息
Ar'Rajab A, Ahrén B
机构信息
Department of Surgery, Lund University, Sweden.
出版信息
Eur J Pharmacol. 1991 Jan 17;192(3):443-5. doi: 10.1016/0014-2999(91)90239-m.
Amidated rat islet amyloid polypeptide (IAPP) is a constituent of secretory granules in islet B-cells. We examined its influence on glucose-stimulated insulin secretion in rats. In vivo, intravenous infusion of IAPP (68 pmol/min) did not affect glucose-stimulated insulin secretion. In vitro, IAPP slightly inhibited glucose (8.3 mM)-stimulated insulin secretion from isolated rat islets at the high dose level of 10(-5) M but not at the lower dose levels. We conclude that the IAPP is not involved in the normal regulation of insulin secretion.
酰胺化大鼠胰岛淀粉样多肽（IAPP）是胰岛β细胞分泌颗粒的一种成分。我们研究了其对大鼠葡萄糖刺激的胰岛素分泌的影响。在体内，静脉输注IAPP（68 pmol/分钟）不影响葡萄糖刺激的胰岛素分泌。在体外，IAPP在高剂量水平10⁻⁵ M时轻微抑制分离的大鼠胰岛对葡萄糖（8.3 mM）刺激的胰岛素分泌，但在较低剂量水平时则无此作用。我们得出结论，IAPP不参与胰岛素分泌的正常调节。
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