用于类风湿性关节炎时辰治疗的双交联脉冲微球的研制与评价
Development and Evaluation of Dual Cross-Linked Pulsatile Beads for Chronotherapy of Rheumatoid Arthritis.
作者信息
Bansal Abanesh Kumar, Pande Vishal
机构信息
Department of Pharmaceutics, H.R. Patel Institute of Pharmaceutical Education and Research, Dhule, Shirpur 425405, Maharashtra, India.
出版信息
J Pharm (Cairo). 2013;2013:906178. doi: 10.1155/2013/906178. Epub 2012 Dec 9.
In the present investigation, pulsatile release beads were prepared by ionic gelation technique. Lornoxicam dual cross-linked beads were prepared by dropping dispersed phase of lornoxicam, pectin, and sodium alginate into the dispersion phase of different concentrations of calcium chloride solution followed by aluminium chloride solution. The formulated beads were further coated by Eudragit L & S 100 in the ratio 1 : 2 w/w in order to achieve desired lag time. In vitro release study showed lag time of 5-8 h before release of lornoxicam from the formulated beads. Thus, formulated dual cross-linked beads when administered at bed time may release lornoxicam when needed most for chronotherapeutics of early morning rheumatoid arthritis attacks in chronic patients.
在本研究中,采用离子凝胶技术制备了脉冲释放微球。通过将氯诺昔康、果胶和海藻酸钠的分散相滴入不同浓度的氯化钙溶液分散相,随后再滴入氯化铝溶液,制备了氯诺昔康双重交联微球。为了达到所需的滞后时间,将制得的微球进一步用Eudragit L & S 100按1∶2 w/w的比例包衣。体外释放研究表明,氯诺昔康从制得的微球中释放前的滞后时间为5 - 8小时。因此,在慢性患者中,当在就寝时间给药时,制得的双重交联微球可能在最需要的时候释放氯诺昔康,用于治疗清晨类风湿性关节炎发作的时间治疗学。