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高剂量苯二氮䓬类药物依赖:关于患者对起始用药、用药原因及获取途径认知的定性研究

High-Dose Benzodiazepine Dependence: A Qualitative Study of Patients' Perceptions on Initiation, Reasons for Use, and Obtainment.

作者信息

Liebrenz Michael, Schneider Marcel, Buadze Anna, Gehring Marie-Therese, Dube Anish, Caflisch Carlo

机构信息

Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric Hospital, University of Zurich, Zurich, Switzerland.

Department of Forensic Psychiatry, Institute of Legal Medicine, University of Bern, Bern, Switzerland.

出版信息

PLoS One. 2015 Nov 10;10(11):e0142057. doi: 10.1371/journal.pone.0142057. eCollection 2015.

Abstract

BACKGROUND

High-dose benzodiazepine (BZD) dependence is associated with a wide variety of negative health consequences. Affected individuals are reported to suffer from severe mental disorders and are often unable to achieve long-term abstinence via recommended discontinuation strategies. Although it is increasingly understood that treatment interventions should take subjective experiences and beliefs into account, the perceptions of this group of individuals remain under-investigated.

METHODS

We conducted an exploratory qualitative study with 41 adult subjects meeting criteria for (high-dose) BZD-dependence, as defined by ICD-10. One-on-one in-depth interviews allowed for an exploration of this group's views on the reasons behind their initial and then continued use of BZDs, as well as their procurement strategies. Mayring's qualitative content analysis was used to evaluate our data.

RESULTS

In this sample, all participants had developed explanatory models for why they began using BZDs. We identified a multitude of reasons that we grouped into four broad categories, as explaining continued BZD use: (1) to cope with symptoms of psychological distress or mental disorder other than substance use, (2) to manage symptoms of physical or psychological discomfort associated with somatic disorder, (3) to alleviate symptoms of substance-related disorders, and (4) for recreational purposes, that is, sensation-seeking and other social reasons. Subjects often considered BZDs less dangerous than other substances and associated their use more often with harm reduction than as recreational. Specific obtainment strategies varied widely: the majority of participants oscillated between legal and illegal methods, often relying on the black market when faced with treatment termination.

CONCLUSIONS

Irrespective of comorbidity, participants expressed a clear preference for medically related explanatory models for their BZD use. We therefore suggest that clinicians consider patients' motives for long-term, high-dose BZD use when formulating treatment plans for this patient group, especially since it is known that individuals are more compliant with approaches they perceive to be manageable, tolerable, and effective.

摘要

背景

高剂量苯二氮䓬(BZD)依赖与多种负面健康后果相关。据报道,受影响的个体患有严重精神障碍,且往往无法通过推荐的停药策略实现长期戒断。尽管人们越来越认识到治疗干预应考虑主观体验和信念,但这一群体的认知仍未得到充分研究。

方法

我们对41名符合ICD - 10定义的(高剂量)BZD依赖标准的成年受试者进行了一项探索性定性研究。通过一对一深入访谈,探讨了该群体对其最初及随后持续使用BZD的原因以及获取策略的看法。采用迈林的定性内容分析法对数据进行评估。

结果

在这个样本中,所有参与者都为自己开始使用BZD建立了解释模型。我们确定了众多原因,并将其归纳为四大类,以解释持续使用BZD的情况:(1)应对除物质使用外的心理困扰或精神障碍症状;(2)处理与躯体疾病相关的身体或心理不适症状;(3)缓解与物质相关的疾病症状;(4)出于娱乐目的,即寻求刺激和其他社交原因。受试者通常认为BZD比其他物质危险性小,且更多地将其使用与减少伤害而非娱乐联系起来。具体的获取策略差异很大:大多数参与者在合法和非法方法之间摇摆不定,在面临治疗终止时往往依赖黑市。

结论

无论是否存在共病,参与者都明确倾向于为其BZD使用采用与医学相关的解释模型。因此,我们建议临床医生在为该患者群体制定治疗计划时,考虑患者长期高剂量使用BZD的动机,特别是因为已知个体对他们认为可控、可耐受且有效的方法更依从。

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