Priest Birgit T, McDermott Jeff S
a Lilly Research Laboratories ; Indianapolis , IN USA.
Channels (Austin). 2015;9(6):352-9. doi: 10.1080/19336950.2015.1076597. Epub 2015 Aug 20.
Ion channels are critical for all aspects of cardiac function, including rhythmicity and contractility. Consequently, ion channels are key targets for therapeutics aimed at cardiac pathophysiologies such as atrial fibrillation or angina. At the same time, off-target interactions of drugs with cardiac ion channels can be the cause of unwanted side effects. This manuscript aims to review the physiology and pharmacology of key cardiac ion channels. The intent is to highlight recent developments for therapeutic development, as well as elucidate potential mechanisms for drug-induced cardiac side effects, rather than present an in-depth review of each channel subtype.
离子通道对心脏功能的各个方面都至关重要,包括节律性和收缩性。因此,离子通道是针对心房颤动或心绞痛等心脏病理生理学的治疗药物的关键靶点。同时,药物与心脏离子通道的脱靶相互作用可能是产生不良副作用的原因。本手稿旨在综述关键心脏离子通道的生理学和药理学。目的是突出治疗药物开发的最新进展,以及阐明药物引起心脏副作用的潜在机制,而不是对每个通道亚型进行深入综述。