RhoA和Rho相关激酶对心血管系统的病理生理影响。
Pathophysiological effects of RhoA and Rho-associated kinase on cardiovascular system.
作者信息
Cai Anping, Li Liwen, Zhou Yingling
机构信息
Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China *Anping Cai and Liwen Li contributed equally to the writing of this article.
出版信息
J Hypertens. 2016 Jan;34(1):3-10. doi: 10.1097/HJH.0000000000000768.
In past decades, growing evidence from basic and clinical researches reveal that small guanosine triphosphate binding protein ras homolog gene family, member A (RhoA) and its main effector Rho-associated kinase (ROCK) play central and complex roles in cardiovascular systems, and increasing RhoA and ROCK activity is associated with a broad range of cardiovascular diseases such as congestive heart failure, atherosclerosis, and hypertension. Favorable outcomes have been observed with ROCK inhibitors treatment. In this review, we briefly summarize the pathophysiological roles of RhoA/ROCK signaling pathway on cardiovascular system, displaying the potential benefits in the cardiovascular system with controlling RhoA/ROCK signaling pathway.
在过去几十年中，基础研究和临床研究越来越多的证据表明，小GTP结合蛋白Ras同源基因家族成员A（RhoA）及其主要效应分子Rho相关激酶（ROCK）在心血管系统中发挥着核心且复杂的作用，RhoA和ROCK活性增加与多种心血管疾病相关，如充血性心力衰竭、动脉粥样硬化和高血压。使用ROCK抑制剂治疗已观察到良好效果。在本综述中，我们简要总结了RhoA/ROCK信号通路在心血管系统中的病理生理作用，展示了通过控制RhoA/ROCK信号通路在心血管系统中的潜在益处。
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